Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 4/20 | 0.45 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | MERTK | Q12866 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17907568 | 0.79 | LMNA (0.54) | LMNA | |
| SCHEMBL2747321 | 0.75 | MAPT (0.68) | MAPTHDAC4HDAC6BRD4SMN1; SMN2 | |
| SCHEMBL18616316 | 0.75 | MERTK (0.57) | MAPTHDAC4HDAC6AXLMERTK | |
| SCHEMBL265154 | 0.75 | DHFR (0.59) | MAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL30560046 | 0.75 | DHFR (0.59) | MAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL28586035 | 0.71 | BMP4 (0.50) | NPC1ALDH1A1HPGDRAB9A | |
| SCHEMBL10195746 | 0.71 | MEN1 (0.69) | MAPTSMN1; SMN2KDM4EMEN1ALDH1A1 | |
| SCHEMBL18389961 | 0.71 | MAPT (0.57) | MAPTHDAC4HDAC6BRD4SMN1; SMN2 | |
| SCHEMBL2376378 | 0.70 | SMN1; SMN2 (0.71) | MAPTSMN1; SMN2KDM4EMEN1NPC1 | |
| SCHEMBL4548020 | 0.70 | POLB (0.69) | MAPTHDAC4HDAC6SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |