Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CHKA | P35790 | 6/20 | 0.51 |
| ▸ | TNIK | Q9UKE5 | 4/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | NCF1 | P14598 | 1/20 | 0.46 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.46 |
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | MC4R | P32245 | 1/20 | 0.45 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL264111 | 0.84 | HRH3 (0.56) | DHFRACVR1PIK3CA | |
| SCHEMBL28586035 | 0.81 | BMP4 (0.50) | — | |
| SCHEMBL14842245 | 0.80 | TNIK (0.61) | TNIKMAP3K11 | |
| SCHEMBL30560046 | 0.80 | DHFR (0.59) | DHFR | |
| SCHEMBL265154 | 0.80 | DHFR (0.59) | DHFR | |
| SCHEMBL4464379 | 0.79 | MAPT (0.50) | LMNA | |
| SCHEMBL16039320 | 0.77 | LMNA (0.58) | LMNACHKATNIKCA2NCF1 | |
| SCHEMBL4472978 | 0.76 | HRH3 (0.56) | DHFR | |
| Hydrochloric Acid SCHEMBL4963320 | 0.76 | JAK2 (0.57) | LMNACHKACA2NCF1PRMT6 | |
| SCHEMBL3588930 | 0.76 | LMNA (0.56) | LMNACHKATNIKCA2NCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951684-B1 | BI-ARYL META-PYRIMIDINE INHIBITORS OF KINASES | TARGEGEN INC (US) | 2016-07-13 | — | — | EP | disclosed |