SCHEMBL4464547

SCHEMBL4464547

COc1cc2c(cc1O)C1(CC2(C)C)CC(C)(C)c2cc(OC)c(O)cc21

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
FTO Q9C0B1 1/20 0.39
MAOB P27338 1/20 0.37
ALDH1A1 P00352 2/20 0.37
NFE2L2 Q16236 1/20 0.37
RXRA P19793 2/20 0.36
LMNA P02545 2/20 0.36
TP53 P04637 2/20 0.36
MITF O75030 1/20 0.36
MAPT P10636 1/20 0.36
TSHR P16473 1/20 0.36
EGFR P00533 1/20 0.36
ACHE P22303 2/20 0.35
CYP3A4 P08684 1/20 0.34
HPGD P15428 1/20 0.34
ALOX15 P16050 1/20 0.34
MAOA P21397 2/20 0.34
CHRNA7 P36544 1/20 0.34
PTGS2 P35354 1/20 0.34
BCHE P06276 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13979784 0.98 FTO (0.38) FTOMAOBALDH1A1NFE2L2RXRA
SCHEMBL12110373 0.98 FTO (0.38) FTOMAOBALDH1A1NFE2L2RXRA
SCHEMBL14539423 0.88 ALOX15 (0.40) FTOALDH1A1RXRALMNATP53
SCHEMBL21730011 0.88 FTO (0.38) FTOALDH1A1LMNATP53MAPT
SCHEMBL11136773 0.87 CA12 (0.41) FTOALDH1A1RXRAMAPTCYP3A4
SCHEMBL21730013 0.86 FTO (0.37) FTOALDH1A1ACHEALOX15MAOA
SCHEMBL29569404 0.82 RXRA (0.35) FTOALDH1A1RXRATP53MAPT
SCHEMBL196263 0.82 RXRA (0.35) FTOALDH1A1RXRATP53MAPT
SCHEMBL4460699 0.81 KCNH2 (0.30)
SCHEMBL8019962 0.81 HNF4A (0.41) ALDH1A1RXRATSHRCYP3A4HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10472467-B2 Polymers having intrinsic microporosity including sub-units with troger's base and spirobisindane moieties DOW GLOBAL TECHNOLOGIES LLC (US) 2019-11-12 US disclosed
US-20190211151-A1 POLYMERS HAVING INTRINSIC MICROPOROSITY INCLUDING SUB-UNITS WITH TROGER'S BASE AND SPIROBISINDANE MOIETIES DOW GLOBAL TECHNOLOGIES LLC (US) 2019-07-11 US disclosed
WO-2015168225-A2 ALKOXY POLYCARBONATES, BISPHENOL MONOMERS AND METHODS OF MAKING AND USING THE SAME SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2015-11-05 WO disclosed
US-9120893-B1 Alkoxy polycarbonates, bisphenol monomers and methods of making and using the same SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2015-09-01 US disclosed
US-9120893-B1 Alkoxy polycarbonates, bisphenol monomers and methods of making and using the same SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2015-09-01 US disclosed
US-7582355-B2 Optical unit using plastic lenses FUJIFILM CORPORATION (JP) 2009-09-01 US disclosed
US-7214834-B2 Process for preparing enantiomerically pure 1,1′-spirobiindane-6,6′-diol derivatives EASTMAN KODAK COMPANY (US) 2007-05-08 US disclosed
US-20060046065-A1 Optical unit using plastic lenses FUJI PHOTO FILM CO., LTD. 2006-03-02 US disclosed
US-6028161-A EXCELLENT TRANSPARENCY, HEAT RESISTANCE AND MECHANICAL PROPERTIES AND A LOW BIREFRINGENCE, MELT FLUIDITY AND MOLDABILITY; AN OPTICAL DISK, LENS AND AN OPTICAL FIBER MITSUI CHEMICALS, INC. (JP) 2000-02-22 US disclosed
EP-0926180-A2 A polycarbonate copolymer and applications thereof Mitsui Chemicals, Inc. (JP) 1999-06-30 EP disclosed