Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL446516 | 0.69 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1OPRM1OPRL1ALDH1A1 | |
| SCHEMBL429907 | 0.67 | ALDH1A1 (0.67) | HSP90AA1HSP90AB1ALDH1A1MAPTNPC1 | |
| SCHEMBL28568186 | 0.65 | OPRM1 (0.50) | OPRM1OPRL1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL449405 | 0.62 | HSP90AA1 (0.54) | HSP90AA1HSP90AB1OPRM1OPRL1ALDH1A1 | |
| SCHEMBL12192283 | 0.60 | HSP90AA1 (0.59) | HSP90AA1HSP90AB1ALDH1A1MAPTPGR | |
| SCHEMBL439012 | 0.59 | HSP90AA1 (0.57) | HSP90AA1HSP90AB1ALDH1A1MAPTNPC1 | |
| SCHEMBL14696825 | 0.58 | MAPT (0.57) | HSP90AA1HSP90AB1ALDH1A1MAPTNPC1 | |
| SCHEMBL2348030 | 0.58 | ALDH1A1 (0.68) | ALDH1A1MAPTSMN1; SMN2 | |
| Ammonia Solution, Strong SCHEMBL29260484 | 0.58 | ALDH1A1 (0.68) | ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL13547967 | 0.58 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1ALDH1A1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065206-A1 | COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS | SYNTA PHARMACEUTICALS CORP. (US) | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065206-A1 | COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS | PKD1, PKD2, PCNA | HSP90AA1 2300/4885HSP90AB1 1711/4885OPRM1 3872/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.