Known targets — ChEMBL curated mechanism
823298382338688239847Rdl1Rdl2Rdl3
The experimentally established mechanism targets of Lindane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.46 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.46 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lindane SCHEMBL3766691 | 0.76 | LMNA (0.50) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| SCHEMBL49256 | 0.74 | — | — | |
| Lindane SCHEMBL9208305 | 0.72 | LMNA (0.36) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL9815928 | 0.72 | LMNA (0.36) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL3809125 | 0.72 | LMNA (0.36) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL10767699 | 0.70 | LMNA (0.33) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| SCHEMBL28296861 | 0.68 | — | — | |
| Fluoride SCHEMBL27257954 | 0.68 | — | — | |
| SCHEMBL27744727 | 0.68 | — | — | |
| Lindane SCHEMBL75689 | 0.67 | LMNA (1.00) | LMNACYP3A4GABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0241739-A1 | Method of modifying surfaces and application of the method in forming layered structures | International Business Machines Corporation (US) | 1987-10-21 | — | — | EP | claimed |
| US-20090012233-A1 | Epoxy Resin Molding Material for Sealing and Electronic Component Device | HITACHI CHEMICAL CO., LTD. (JP) | 2009-01-08 | — | — | US | disclosed |
| EP-0912473-B1 | METHYLATION OF TOLUENE TO PARA-XYLENE | EXXONMOBIL CHEM PATENTS INC (US) | 2003-04-16 | — | — | EP | disclosed |
| EP-0914311-B1 | PROCESS FOR PRODUCING AROMATIC COMPOUNDS FROM ALIPHATIC HYDROCARBONS | EXXONMOBIL CHEM PATENTS INC (US) | 2001-07-11 | — | — | EP | disclosed |
| US-5998686-A | AROMATIZATION BY DEHYDROCYCLIZATION, OLIGOMERIZATION USING ZEOLITE CATALYST | EXXON CHEMICAL PATENTS INC. (US) | 1999-12-07 | — | — | US | disclosed |
| US-5994603-A | CATALYST COMPRISES FIRST ZEOLITE CRYSTALS WHICH ARE BOUND TOGETHER BY SECOND ZEOLITE CRYSTALS. | EXXON CHEMICAL PATENTS INC. (US) | 1999-11-30 | — | — | US | disclosed |
| EP-0914311-A1 | PROCESS FOR PRODUCING AROMATIC COMPOUNDS FROM ALIPHATIC HYDROCARBONS | EXXON CHEMICAL PATENTS INC. (US) | 1999-05-12 | — | — | EP | disclosed |
| EP-0912473-A1 | METHYLATION OF TOLUENE TO PARA-XYLENE | EXXON CHEMICAL PATENTS INC. (US) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997045387-A1 | METHYLATION OF TOLUENE TO PARA-XYLENE | EXXON CHEMICAL PATENTS INC. (US) | 1997-12-04 | — | — | WO | disclosed |
| WO-1997045386-A1 | PROCESS FOR PRODUCING AROMATIC COMPOUNDS FROM ALIPHATIC HYDROCARBONS | EXXON CHEMICAL PATENTS INC. (US) | 1997-12-04 | — | — | WO | disclosed |
| EP-0332042-A1 | Aromatic compounds substituted by 4,6-bis-trichloromethyl-s-triazin-2-yl groups, process for their preparation and their use in photosensitive mixtures | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-09-13 | — | — | EP | disclosed |
| EP-0332043-A1 | Oxadiazole derivatives containing 4,6-bis-trichloromethyl-s-triazin-2-yl groups, process for their preparation and photosensitive mixture containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-09-13 | — | — | EP | disclosed |