Known targets — ChEMBL curated mechanism
823298382338688239847Rdl1Rdl2Rdl3
The experimentally established mechanism targets of Lindane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL528410 | 0.80 | — | — | |
| Lindane SCHEMBL4466086 | 0.72 | LMNA (0.46) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL8470986 | 0.69 | — | — | |
| Lindane SCHEMBL5667613 | 0.69 | — | — | |
| Lindane SCHEMBL6508076 | 0.69 | — | — | |
| Lindane SCHEMBL9845655 | 0.68 | LMNA (0.50) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL3766691 | 0.68 | LMNA (0.50) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL9209782 | 0.67 | — | — | |
| Lindane SCHEMBL3097219 | 0.65 | LMNA (0.46) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL10416102 | 0.65 | ALDH1A1 (0.55) | LMNACYP3A4GABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0444068-A1 | TRIALKYSILYL ESTERS OF AMINO ACIDS AND THEIR USE IN THE SYNTHESIS OF PEPTIDES | PUBLIC HEALTH LABORATORY SERVICE BOARD (GB) | 1991-09-04 | — | — | EP | disclosed |
| WO-1990005738-A1 | TRIALKYSILYL ESTERS OF AMINO ACIDS AND THEIR USE IN THE SYNTHESIS OF PEPTIDES | PUBLIC HEALTH LABORATORY SERVICE BOARD (GB) | 1990-05-31 | — | — | WO | disclosed |