Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.36 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 3/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | BCL9 | O00512 | 1/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1884641 | 0.79 | GRIA1 (0.67) | GRIA1GRIA3PDE4DGRM5 | |
| SCHEMBL4466632 | 0.78 | MCHR1 (0.43) | GRIA1GRIA3PDE4DCYP1A2CYP2D6 | |
| SCHEMBL4466635 | 0.76 | ABL1 (0.39) | PDE10AABL1BCRGRIA1GRIA3 | |
| SCHEMBL687912 | 0.75 | GRIA1 (0.51) | GRIA1GRIA3PDE4DCYP1A2CYP2D6 | |
| SCHEMBL2782807 | 0.75 | GRIA1 (0.42) | GRIA1GRIA3PDE4DGRM5HTR1A | |
| SCHEMBL4072861 | 0.71 | MAPK10 (0.44) | CYP1A2CYP2D6CYP2C9CYP2C19GRM5 | |
| SCHEMBL1883876 | 0.68 | GRIA1 (0.65) | GRIA1GRIA3PDE4DGRM5 | |
| SCHEMBL14889241 | 0.68 | GRIA1 (0.62) | GRIA1GRIA3PDE4DGRM5HTR1A | |
| SCHEMBL1885107 | 0.67 | SMN1; SMN2 (0.45) | ABL1GRIA1GRIA3PDE4DCYP1A2 | |
| SCHEMBL1886861 | 0.66 | ABL1 (0.46) | ABL1BCRGRIA1GRIA3PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009054543-A1 | AMPA RECEPTOR ANTAGONISTS AND ZONISAMIDE FOR PARKINSON'S DISEASE AND MOVEMENT DISORDERS | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-04-30 | — | — | WO | disclosed |