Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.51 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | BLM | P54132 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | TNKS | O95271 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | CCR8 | P51685 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2782807 | 0.84 | GRIA1 (0.42) | GRIA1GRIA3PDE4DGRM5MAPT | |
| SCHEMBL1885107 | 0.84 | SMN1; SMN2 (0.45) | GRIA1GRIA3PDE4DKDM4ECYP1A2 | |
| SCHEMBL10059844 | 0.83 | TNKS (0.57) | GRIA1GRIA3PDE4DKDM4ECYP1A2 | |
| SCHEMBL1887704 | 0.77 | GRIA1 (0.71) | GRIA1GRIA3PDE4DKDM4ECYP1A2 | |
| SCHEMBL10021078 | 0.77 | ALDH1A1 (0.60) | KDM4ECYP1A2BLMALDH1A1HPGD | |
| SCHEMBL14889241 | 0.77 | GRIA1 (0.62) | GRIA1GRIA3PDE4DGRM5HTR1A | |
| SCHEMBL1890140 | 0.77 | GRIA1 (0.67) | GRIA1GRIA3PDE4DTNKSCYP2A6 | |
| SCHEMBL10059523 | 0.77 | ALDH1A1 (0.51) | KDM4ECYP1A2BLMALDH1A1HPGD | |
| SCHEMBL21475947 | 0.77 | DYRK1A (0.55) | KDM4ECYP1A2BLMCYP2A6LMNA | |
| SCHEMBL18088205 | 0.77 | TP53 (0.44) | KDM4ECYP1A2BLMALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109799298-B | Detection method of related substances in Perampanel bulk drug | 南京海纳医药科技股份有限公司 | 2022-01-07 | — | — | CN | claimed |
| CN-109342603-B | Detection method of perampanel tablet related substances | 南京海纳医药科技股份有限公司 | 2020-08-21 | — | — | CN | claimed |
| CN-118851993-A | Method for removing metal impurities in pirenzenenaphthalene | 锦州奥鸿药业有限责任公司 | 2024-10-29 | — | — | CN | disclosed |
| CN-109799298-B | Detection method of related substances in Perampanel bulk drug | 南京海纳医药科技股份有限公司 | 2022-01-07 | — | — | CN | disclosed |
| CN-109342603-B | Detection method of perampanel tablet related substances | 南京海纳医药科技股份有限公司 | 2020-08-21 | — | — | CN | disclosed |
| CN-110028442-B | Simple preparation method of Perampanel | 新发药业有限公司 | 2020-07-17 | — | — | CN | disclosed |
| US-10111867-B2 | Process and intermediates for the preparation of perampanel | MAPI PHARMA LTD. (IL) | 2018-10-30 | — | — | US | disclosed |
| US-20180008584-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF PERAMPANEL | MAPI PHARMA LTD. (IL) | 2018-01-11 | — | — | US | disclosed |
| US-20180008584-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF PERAMPANEL | MAPI PHARMA LTD. (IL) | 2018-01-11 | — | — | US | disclosed |
| EP-3259262-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF PERAMPANEL | Mapi Pharma Limited (IL) | 2017-12-27 | — | — | EP | disclosed |
| EP-3024821-B1 | PROCESS FOR THE PREPARATION OF PERAMPANEL | TEVA PHARMACEUTICALS INT GMBH (CH) | 2017-09-27 | — | — | EP | disclosed |
| CN-1738618-A | Pharmaceutical compositions and their uses | EISAI CO LTD (JP) | 2006-02-22 | — | — | CN | disclosed |
| US-20050245581-A1 | 1, 2-Dihydropyridine compounds, manufacturing method thereof and use thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2005-11-03 | — | — | US | disclosed |
| US-6949571-B2 | 1,2-dihydropyridine compounds, process for preparation of the same and use thereof | EISAI CO., LTD. (JP) | 2005-09-27 | — | — | US | disclosed |
| EP-1465626-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING DIHYDROPYRIDINONE COMPOUNDS AND AN IMMUNOREGULATORY OR AN ANTIINFLAMMATORY AGENT AND THEIR USES | Eisai Co., Ltd. (JP) | 2004-10-13 | — | — | EP | disclosed |
| US-20040023973-A1 | 1,2-Dihydropyridine compounds, process for preparation of the same and use thereof | CATALYST PHARMACEUTICALS, INC. | 2004-02-05 | — | — | US | disclosed |
| CN-1436172-A | 1, 2-dihydropyridine compound, preparation method and application thereof | EISAI CO LTD (JP) | 2003-08-13 | — | — | CN | disclosed |
| WO-2003047577-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING DIHYDROPYRIDINONE COMPOUNDS AND AN IMMUNOREGULATORY OR AN ANTIINFLAMMATORY AGENT AND THEIR USES | EISAI CO LTD (JP) | 2003-06-12 | — | — | WO | disclosed |
| WO-2003047577-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING DIHYDROPYRIDINONE COMPOUNDS AND AN IMMUNOREGULATORY OR AN ANTIINFLAMMATORY AGENT AND THEIR USES | EISAI CO LTD (JP) | 2003-06-12 | — | — | WO | disclosed |
| EP-1300396-A1 | 1,2-DIHYDROPYRIDINE COMPOUNDS, PROCESS FOR PREPARATION OF THE SAME AND USE THEREOF | Eisai Co., Ltd. (JP) | 2003-04-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040023973-A1 | 1,2-Dihydropyridine compounds, process for preparation of the same and use thereof | GRIK1, GRIK2, GRIK4 | GRIA1 14/4885GRIA3 58/4885PDE4D 2584/4885 |
| US-20050245581-A1 | 1, 2-Dihydropyridine compounds, manufacturing method thereof and use thereof | GRIK1, GRIK2, GRIK5 | GRIA1 24/4885GRIA3 46/4885PDE4D 1607/4885 |
| US-20180008584-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF PERAMPANEL | PDXK, P2RY1, ADH1A | GRIA1 1230/4885GRIA3 1843/4885PDE4D 1383/4885 |
| US-10111867-B2 | Process and intermediates for the preparation of perampanel | PDXK, P2RY1, ADH1A | GRIA1 1230/4885GRIA3 1843/4885PDE4D 1383/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.