Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.42 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.41 |
| ▸ | GRM5 | P41594 | 2/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.40 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.40 |
| ▸ | COMT | P21964 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687912 | 0.84 | GRIA1 (0.51) | GRIA1GRIA3PDE4DGRM5MAPT | |
| SCHEMBL1881456 | 0.81 | GRIA1 (0.47) | GRIA1GRIA3PDE4DFGFR1OPRD1 | |
| SCHEMBL1882491 | 0.77 | GRIA1 (0.56) | GRIA1GRIA3PDE4DFGFR1GRM5 | |
| SCHEMBL14889241 | 0.77 | GRIA1 (0.62) | GRIA1GRIA3PDE4DGRM5HTR1A | |
| SCHEMBL1885107 | 0.76 | SMN1; SMN2 (0.45) | GRIA1GRIA3PDE4DFGFR1RET | |
| SCHEMBL4466632 | 0.76 | MCHR1 (0.43) | GRIA1GRIA3PDE4DFGFR1ESR1 | |
| SCHEMBL4466635 | 0.76 | ABL1 (0.39) | GRIA1GRIA3PDE4DGRM5 | |
| SCHEMBL1884288 | 0.75 | GRIA1 (0.60) | GRIA1GRIA3PDE4DOPRD1GRM5 | |
| SCHEMBL4466629 | 0.75 | PDE10A (0.41) | GRIA1GRIA3PDE4DGRM5HTR1A | |
| SCHEMBL10059952 | 0.75 | HSD17B1 (0.48) | OPRD1HSD17B1HSD17B2COMTESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2177520-A1 | 1,5-Di(aryl or heteroaryl)-3-halo-2(1H)-pyridones as intermediates for the preparation of AMPA receptor inhibitors | Eisai R&D Management Co., Ltd. (JP) | 2010-04-21 | — | — | EP | disclosed |