Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1891168 | 0.82 | GRIA1 (0.52) | MCHR1FGFR1SRCACVR1BTGFBR1 | |
| SCHEMBL1881496 | 0.81 | GRIA1 (0.49) | MCHR1FGFR1SRCACVR1BTGFBR1 | |
| SCHEMBL4466635 | 0.81 | ABL1 (0.39) | CYP1A2CYP2D6CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL1884643 | 0.79 | GRIA1 (0.69) | FGFR1SRCACVR1BTGFBR1ADORA2A | |
| SCHEMBL1884751 | 0.79 | GRIA1 (0.53) | MCHR1FGFR1SRCACVR1BTGFBR1 | |
| SCHEMBL4466629 | 0.78 | PDE10A (0.41) | TGFBR1CYP1A2CYP2D6CYP19A1CYP2C9 | |
| SCHEMBL687912 | 0.76 | GRIA1 (0.51) | TGFBR1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL1886583 | 0.76 | GRIA1 (0.67) | FGFR1SRCADORA2AADORA1KDM4E | |
| SCHEMBL2782807 | 0.76 | GRIA1 (0.42) | FGFR1ESR1GRIA1GRIA3PDE4D | |
| SCHEMBL4138229 | 0.75 | CYP2D6 (0.69) | ACVR1BTGFBR1CHRNB2CHRNA4ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009054543-A1 | AMPA RECEPTOR ANTAGONISTS AND ZONISAMIDE FOR PARKINSON'S DISEASE AND MOVEMENT DISORDERS | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-04-30 | — | — | WO | disclosed |