Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | BCR | P11274 | 2/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.36 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1891167 | 0.81 | GRIA1 (0.51) | ABL1BCRGRIA1GRIA3PDE4D | |
| SCHEMBL4466632 | 0.81 | MCHR1 (0.43) | GRIA1GRIA3PDE4DCYP1A2CYP2D6 | |
| SCHEMBL1881495 | 0.81 | GRIA1 (0.48) | ABL1BCRGRIA1GRIA3PDE4D | |
| SCHEMBL1884645 | 0.79 | GRIA1 (0.68) | ABL1BCRGRIA1GRIA3PDE4D | |
| SCHEMBL1884749 | 0.78 | GRIA1 (0.53) | GRIA1GRIA3PDE4DGABRG2GABRB3 | |
| SCHEMBL687912 | 0.76 | GRIA1 (0.51) | GRIA1GRIA3PDE4DGRM5CYP1A2 | |
| SCHEMBL4466629 | 0.76 | PDE10A (0.41) | ABL1BCRGRIA1GRIA3PDE4D | |
| SCHEMBL2782807 | 0.76 | GRIA1 (0.42) | GRIA1GRIA3PDE4DGRM5 | |
| SCHEMBL1882344 | 0.71 | GRIA1 (0.49) | GRIA1GRIA3PDE4DGRM5GABRG2 | |
| SCHEMBL1883880 | 0.69 | GRIA1 (0.65) | GRIA1GRIA3PDE4DGRM5GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009054543-A1 | AMPA RECEPTOR ANTAGONISTS AND ZONISAMIDE FOR PARKINSON'S DISEASE AND MOVEMENT DISORDERS | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-04-30 | — | — | WO | disclosed |