SCHEMBL4467781

SCHEMBL4467781

COC1=CCC(=C2Oc3c(O)c(O)cc(O)c3C(=O)C2=O)C=C1O

nearest known ligand 0.32

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.31
POLB P06746 1/20 0.31
MAPT P10636 1/20 0.31
GAA P10253 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4470549 0.81 HKDC1 (0.39)
SCHEMBL4739994 0.62 PIK3CA (0.37) POLBMAPTSMN1; SMN2
SCHEMBL23271765 0.60 KDM4E (0.43) KDM4EMAPTSMN1; SMN2
SCHEMBL30003486 0.60 KDM4E (0.43) KDM4EMAPTSMN1; SMN2
SCHEMBL3485829 0.56 PLK1 (0.31)
SCHEMBL3513421 0.56 TYR (0.40)
SCHEMBL7115300 0.54 ADORA3 (0.37) KDM4EPOLBMAPT
SCHEMBL15414521 0.53 TYR (0.40)
SCHEMBL11919734 0.53 ELANE (0.56) KDM4EPOLBMAPT
SCHEMBL11919735 0.53 ELANE (0.56) KDM4EPOLBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7582675-B2 Flavonoid compound and process for producing the same POKKA CORPORATION (JP) 2009-09-01 US disclosed
US-20060270009-A1 Flavonoid compound and process for producing the same NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (JP) 2006-11-30 US disclosed
US-7138429-B2 Flavonoid compound and process for producing the same JAPAN SCI. TECH. CORP. (JP) 2006-11-21 US disclosed
EP-1369489-B1 FLAVONOID COMPOUND AND PROCESS FOR PRODUCING THE SAME JAPAN SCIENCE & TECH CORP (JP) 2006-08-23 EP disclosed
US-20040152762-A1 Flavonoid compound and process for producing the same NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (JP) 2004-08-05 US disclosed
EP-1369489-A1 FLAVONOID COMPOUND AND PROCESS FOR PRODUCING THE SAME Japan Science and Technology Corporation (JP) 2003-12-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040152762-A1 Flavonoid compound and process for producing the same ERG28, TFPI, HES1 KDM4E 1126/4885POLB 2116/4885MAPT 3583/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.