Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | MCOLN3 | Q8TDD5 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6025006 | 0.85 | ALDH1A1 (0.63) | TSHRALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL28254881 | 0.80 | TSHR (0.55) | TSHRALDH1A1GAANPBWR1KDM4E | |
| SCHEMBL11167261 | 0.79 | TSHR (0.63) | TSHRALDH1A1GAANPBWR1KDM4E | |
| SCHEMBL4464439 | 0.79 | TSHR (0.50) | TSHRALDH1A1GAANPBWR1KDM4E | |
| SCHEMBL17008468 | 0.75 | TSHR (0.74) | TSHRALDH1A1GAANPBWR1KDM4E | |
| SCHEMBL29736855 | 0.75 | TSHR (0.74) | TSHRALDH1A1GAANPBWR1KDM4E | |
| SCHEMBL6034809 | 0.75 | KDM4E (0.47) | TSHRALDH1A1GAANPBWR1KDM4E | |
| SCHEMBL6035064 | 0.74 | PKM (0.56) | TSHRALDH1A1GAANPBWR1KDM4E | |
| SCHEMBL29944324 | 0.74 | KMT2A (0.74) | TSHRALDH1A1GAANPBWR1KDM4E | |
| SCHEMBL10570472 | 0.74 | TSHR (0.89) | TSHRALDH1A1GAANPBWR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7576088-B2 | Benzodioxole derivatives | HOFFMAN-LA ROCHE INC. (US) | 2009-08-18 | — | — | US | disclosed |
| CN-100486973-C | Novel benzodioxoles | HOFFMANN LA ROCHE (CH) | 2009-05-13 | — | — | CN | disclosed |
| EP-1532132-B1 | NOVEL BENZODIOXOLES | HOFFMANN LA ROCHE (CH) | 2008-03-19 | — | — | EP | disclosed |
| CN-1671684-A | New benzodioxoles | HOFFMANN LA ROCHE (CH) | 2005-09-21 | — | — | CN | disclosed |
| US-20050143373-A1 | Benzodioxole derivatives | ALANINE ALEXANDER (FR) | 2005-06-30 | — | — | US | disclosed |
| US-6900227-B2 | Benzodioxole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2005-05-31 | — | — | US | disclosed |
| EP-1532132-A1 | NOVEL BENZODIOXOLES | F.HOFFMANN-LA ROCHE AG (CH) | 2005-05-25 | — | — | EP | disclosed |
| US-20040142922-A1 | Benzodioxole derivatives | HOFFMANN-LA ROCHE INC. | 2004-07-22 | — | — | US | disclosed |
| WO-2004013120-A1 | NOVEL BENZODIOXOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-02-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050143373-A1 | Benzodioxole derivatives | CNR2, CNR1, GPR119 | TSHR 1029/4885ALDH1A1 607/4885GAA 1684/4885 |
| US-20040142922-A1 | Benzodioxole derivatives | CNR1, CNR2, GPR119 | TSHR 1171/4885ALDH1A1 299/4885GAA 1559/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.