Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4482279 | 1.00 | OPRM1 (0.43) | OPRM1OPRD1OPRK1ARNPC1 | |
| SCHEMBL4466399 | 0.93 | AR (0.47) | ARKMT2ASRD5A2SRD5A1 | |
| SCHEMBL13610944 | 0.93 | AR (0.47) | ARKMT2ASRD5A2SRD5A1 | |
| SCHEMBL4466397 | 0.93 | AR (0.47) | ARKMT2ASRD5A2SRD5A1 | |
| SCHEMBL13603575 | 0.93 | AR (0.47) | ARKMT2ASRD5A2SRD5A1 | |
| SCHEMBL4471645 | 0.90 | PKM (0.43) | ARSRD5A2SRD5A1 | |
| SCHEMBL4471639 | 0.90 | PKM (0.43) | ARSRD5A2SRD5A1 | |
| SCHEMBL4462134 | 0.85 | ALDH1A1 (0.42) | SRD5A2SRD5A1 | |
| SCHEMBL4462128 | 0.85 | ALDH1A1 (0.42) | SRD5A2SRD5A1 | |
| SCHEMBL4472214 | 0.85 | SRD5A2 (0.50) | SRD5A2SRD5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625919-B2 | 4-azasteroid derivatives as androgen receptor modulators | MERCK & CO., INC. (US) | 2009-12-01 | — | — | US | claimed |
| US-20060281761-A1 | 4-azasteroid derivatives as androgen receptor modulators | MERCK SHARP & DOHME CORP. | 2006-12-14 | — | — | US | claimed |
| US-20050131005-A1 | 4-azasteroid derivatives as androgen receptor modulators | WANG JIABING (US) | 2005-06-16 | — | — | US | claimed |
| EP-1501512-A2 | 4-AZASTEROID DERIVATIVES AS ANDROGEN RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2005-02-02 | — | — | EP | claimed |
| WO-2003092588-A2 | 4-AZASTEROID DERIVATIVES AS ANDROGEN RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2003-11-13 | — | — | WO | claimed |
| US-7625919-B2 | 4-azasteroid derivatives as androgen receptor modulators | MERCK & CO., INC. (US) | 2009-12-01 | — | — | US | disclosed |
| US-20060281761-A1 | 4-azasteroid derivatives as androgen receptor modulators | MERCK SHARP & DOHME CORP. | 2006-12-14 | — | — | US | disclosed |
| US-20050131005-A1 | 4-azasteroid derivatives as androgen receptor modulators | WANG JIABING (US) | 2005-06-16 | — | — | US | disclosed |
| EP-1501512-A2 | 4-AZASTEROID DERIVATIVES AS ANDROGEN RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003092588-A2 | 4-AZASTEROID DERIVATIVES AS ANDROGEN RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2003-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060281761-A1 | 4-azasteroid derivatives as androgen receptor modulators | NR5A1, AR, NR3C1 | OPRM1 2335/4885OPRD1 710/4885OPRK1 1715/4885 |
| US-20050131005-A1 | 4-azasteroid derivatives as androgen receptor modulators | AR, NR5A1, NR3C1 | OPRM1 2404/4885OPRD1 740/4885OPRK1 1791/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.