Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.35 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | NPY1R | P25929 | 1/20 | 0.33 |
| ▸ | NPY2R | P49146 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4516101 | 0.82 | FLT1 (0.40) | FLT1FLT4KDRMAPTALDH1A1 | |
| SCHEMBL4483753 | 0.81 | SIK1 (0.38) | MAPTALDH1A1NPC1GPR27KDM4E | |
| SCHEMBL132169 | 0.75 | ALDH1A1 (0.61) | FLT1FLT4KDRMAPTALDH1A1 | |
| SCHEMBL15277187 | 0.73 | FLT1 (0.37) | FLT1FLT4KDRMAPTALDH1A1 | |
| SCHEMBL4470182 | 0.72 | RAB9A (0.53) | FLT1FLT4KDRMAPTALDH1A1 | |
| SCHEMBL29608371 | 0.71 | ALDH1A1 (0.47) | FLT1FLT4KDRMAPTALDH1A1 | |
| SCHEMBL2170651 | 0.71 | HPGD (0.57) | MAPTALDH1A1UTS2RNPC1MAPK1 | |
| SCHEMBL3251690 | 0.71 | ALDH1A1 (0.44) | FLT1FLT4KDRMAPTALDH1A1 | |
| SCHEMBL428805 | 0.71 | DGAT1 (0.60) | FLT1FLT4KDRMAPTDGAT1 | |
| SCHEMBL4474154 | 0.71 | PLAU (0.52) | MAPTALDH1A1NPC1HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009094205-A2 | 3-ARYL-6-ARYL-7H-[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2009-07-30 | — | — | WO | disclosed |