Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIK1 | P57059 | 1/20 | 0.38 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.38 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27007710 | 0.88 | ALDH1A1 (0.44) | SIK1SIK2SIK3ALDH1A1HPGD | |
| SCHEMBL4474154 | 0.84 | PLAU (0.52) | ALDH1A1HPGDRAD52PLAUMAPT | |
| SCHEMBL2486625 | 0.84 | ALDH1A1 (0.41) | SIK1SIK2SIK3ALDH1A1HPGD | |
| SCHEMBL4470184 | 0.81 | FLT1 (0.37) | ALDH1A1GPR27MAPTCYP2C9CYP2C19 | |
| SCHEMBL18340040 | 0.77 | ALDH1A1 (0.56) | SIK1SIK2SIK3ALDH1A1HPGD | |
| SCHEMBL4502460 | 0.75 | PIN1 (0.40) | CLK1MAPTSMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL17319164 | 0.75 | KMT2A (0.44) | ALDH1A1HPGDGPR27CLK1MAPT | |
| SCHEMBL4483750 | 0.74 | RAB9A (0.52) | ALDH1A1GPR27CLK1MAPTGFER | |
| SCHEMBL423775 | 0.74 | PARP15 (0.58) | SIK1SIK2SIK3ALDH1A1HPGD | |
| SCHEMBL4527090 | 0.73 | KMT2A (0.48) | ALDH1A1HPGDMAPTSMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009094205-A2 | 3-ARYL-6-ARYL-7H-[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2009-07-30 | — | — | WO | disclosed |