Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8013186 | 0.72 | NCOA1 (0.44) | PDE10AMAPTALDH1A1L3MBTL1TDP1 | |
| SCHEMBL638537 | 0.71 | ALDH1A1 (0.38) | MAPTALDH1A1TDP1RAB9ASMN1; SMN2 | |
| SCHEMBL6270882 | 0.68 | LMNA (0.43) | MAPTALDH1A1L3MBTL1TDP1RAB9A | |
| SCHEMBL9381631 | 0.68 | LMNA (0.43) | MAPTALDH1A1L3MBTL1TDP1SMN1; SMN2 | |
| SCHEMBL1128345 | 0.67 | CYP3A4 (0.43) | MAPTALDH1A1TDP1RAB9ASMN1; SMN2 | |
| SCHEMBL5777939 | 0.67 | ALDH1A1 (0.47) | PDE10AMAPTALDH1A1L3MBTL1TDP1 | |
| Phenanthroline SCHEMBL8685304 | 0.66 | MAPT (0.70) | PDE10AMAPTALDH1A1L3MBTL1TDP1 | |
| Phenanthroline SCHEMBL8685400 | 0.66 | MAPT (0.70) | PDE10AMAPTALDH1A1L3MBTL1TDP1 | |
| Phenanthroline SCHEMBL11763405 | 0.66 | MAPT (0.70) | PDE10AMAPTALDH1A1L3MBTL1TDP1 | |
| Phenanthroline SCHEMBL8686231 | 0.66 | MAPT (0.70) | PDE10AMAPTALDH1A1L3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009140215-A2 | METHOD FOR TREATING DRUG-RESISTANT BACTERIAL AND OTHER INFECTIONS WITH CLIOQUINOL, PHANQUINONE, AND RELATED COMPOUNDS | GERAGHTY, ERIN (US) | 2009-11-19 | — | — | WO | claimed |
| WO-2009140215-A2 | METHOD FOR TREATING DRUG-RESISTANT BACTERIAL AND OTHER INFECTIONS WITH CLIOQUINOL, PHANQUINONE, AND RELATED COMPOUNDS | GERAGHTY, ERIN (US) | 2009-11-19 | — | — | WO | disclosed |