Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 6/20 | 0.36 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4498185 | 0.83 | ALDH1A1 (0.68) | KMT2AALDH1A1GAAMAPK1MEN1 | |
| SCHEMBL4454520 | 0.68 | MAPT (0.47) | KMT2AALDH1A1GAAMEN1MAPT | |
| SCHEMBL4502462 | 0.65 | ALDH1A1 (0.69) | KMT2AALDH1A1GAAMEN1MAPT | |
| SCHEMBL4453819 | 0.65 | ALDH1A1 (0.48) | KMT2AALDH1A1GAAMEN1MAPT | |
| SCHEMBL4495436 | 0.62 | ATM (0.55) | KMT2AALDH1A1GAAMEN1MAPT | |
| SCHEMBL7083963 | 0.62 | ALDH1A1 (0.66) | KMT2AALDH1A1GAAMEN1MAPT | |
| SCHEMBL9955263 | 0.61 | KMT2A (0.60) | KMT2AALDH1A1MEN1MAPTKDM4E | |
| SCHEMBL4456504 | 0.59 | ALDH1A1 (0.56) | KMT2AALDH1A1GAAMEN1MAPT | |
| SCHEMBL14936573 | 0.59 | GAA (0.47) | KMT2AALDH1A1GAAMAPK1MEN1 | |
| SCHEMBL4465659 | 0.59 | KMT2A (0.43) | KMT2AALDH1A1GAAMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010534-A1 | THIOXANTHINE DERIVATIVES AND THEIR USE AS INHIBITORS OF MPO | AstraZeneca AB (SE) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007120097-A1 | THIOXANTHINE DERIVATIVES AND THEIR USE AS INHIBITORS OF MPO | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | WO | disclosed |