Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | GAA | P10253 | 4/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MPO | P05164 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4471420 | 0.83 | KMT2A (0.49) | ALDH1A1KMT2AGAAMAPK1L3MBTL1 | |
| SCHEMBL4502462 | 0.78 | ALDH1A1 (0.69) | ALDH1A1KMT2AGAAHSD17B10HPGD | |
| SCHEMBL4453819 | 0.78 | ALDH1A1 (0.48) | ALDH1A1KMT2AGAAHSD17B10HPGD | |
| SCHEMBL4495436 | 0.74 | ATM (0.55) | ALDH1A1KMT2AGAAHPGDKDM4E | |
| SCHEMBL7083963 | 0.74 | ALDH1A1 (0.66) | ALDH1A1KMT2AGAAHSD17B10HPGD | |
| SCHEMBL4454520 | 0.74 | MAPT (0.47) | ALDH1A1KMT2AGAAHSD17B10HPGD | |
| SCHEMBL4456504 | 0.71 | ALDH1A1 (0.56) | ALDH1A1KMT2AGAAHSD17B10HPGD | |
| SCHEMBL9955263 | 0.70 | KMT2A (0.60) | ALDH1A1KMT2AHSD17B10HPGDL3MBTL1 | |
| SCHEMBL4456847 | 0.70 | MPO (0.46) | ALDH1A1KMT2AGAAL3MBTL1KDM4E | |
| SCHEMBL7255769 | 0.69 | ALDH1A1 (0.60) | ALDH1A1KMT2AGAAHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090286813-A1 | Thioxanthine Derivatives and Their Use as Inhibitors of MPO | ASTRAZENECA AB (SE) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286813-A1 | Thioxanthine Derivatives and Their Use as Inhibitors of MPO | MPO, XDH, EPX | ALDH1A1 296/4885KMT2A 2979/4885GAA 602/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.