Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 4/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3136125 | 0.71 | ADORA1 (0.45) | ADORA1ADORA2AADORA2BALDH1A1KDM4E | |
| SCHEMBL1567456 | 0.70 | ADORA1 (0.57) | ADORA1ADORA2AADORA2BMEN1KMT2A | |
| SCHEMBL9173396 | 0.68 | ADORA1 (0.56) | ADORA1ADORA2AADORA2BKDM4EPDE4A | |
| SCHEMBL3223903 | 0.66 | PDE4A (0.55) | ADORA1ADORA2AADORA2BALDH1A1KDM4E | |
| SCHEMBL9168640 | 0.65 | KMT2A (0.74) | ADORA1ADORA2AADORA2BALDH1A1KDM4E | |
| SCHEMBL9174459 | 0.65 | ADORA1 (0.52) | ADORA1ADORA2AADORA2BALDH1A1KDM4E | |
| SCHEMBL3227594 | 0.64 | PDE4A (0.55) | ADORA1ADORA2AADORA2BALDH1A1KDM4E | |
| SCHEMBL5227560 | 0.64 | ADORA1 (0.90) | ADORA1ADORA2AADORA2BMEN1KMT2A | |
| SCHEMBL4445208 | 0.63 | PDE4A (0.54) | ADORA1ADORA2AADORA2BALDH1A1KDM4E | |
| SCHEMBL9167613 | 0.63 | ADORA1 (0.50) | ADORA1ADORA2AADORA2BALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579354-B2 | Adenosine receptor antagonists and methods of making and using the same | KIESMAN WILLIAM F | 2009-08-25 | — | — | US | disclosed |
| US-20060252730-A1 | Adenosine receptor antagonists and methods of making and using the same | KIESMAN WILLIAM F | 2006-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252730-A1 | Adenosine receptor antagonists and methods of making and using the same | ADORA1, ADORA2A, ADORA3 | ADORA1 1/4885ADORA2A 2/4885ADORA2B 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.