Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 6/20 | 0.53 |
| ▸ | HTR1A | P08908 | 5/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.50 |
| ▸ | HTR2C | P28335 | 3/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7781578 | 0.85 | DRD2 (0.62) | KDM4EALDH1A1TDP1DRD2HTR1A | |
| SCHEMBL7782280 | 0.84 | ADRA1A (0.61) | KDM4EALDH1A1TDP1DRD2HTR1A | |
| SCHEMBL2959968 | 0.81 | HTR6 (0.54) | — | |
| SCHEMBL2959964 | 0.81 | HTR6 (0.54) | — | |
| SCHEMBL27157955 | 0.81 | SCN9A (0.55) | — | |
| SCHEMBL13373038 | 0.80 | ACKR3 (0.48) | KDM4EHTR2CHTR2A | |
| SCHEMBL13373031 | 0.80 | ACKR3 (0.48) | KDM4EHTR2CHTR2A | |
| SCHEMBL13373030 | 0.80 | ACKR3 (0.48) | KDM4EHTR2CHTR2A | |
| SCHEMBL246048 | 0.79 | TSHR (0.58) | KDM4EALDH1A1TDP1DRD2 | |
| SCHEMBL246627 | 0.79 | TSHR (0.63) | ALDH1A1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7511141-B2 | Piperidine-piperazine ligands for neurotransmitter receptors | SEPRACOR, INC. (US) | 2009-03-31 | — | — | US | disclosed |
| US-7511141-B2 | Piperidine-piperazine ligands for neurotransmitter receptors | SEPRACOR, INC. (US) | 2009-03-31 | — | — | US | disclosed |
| US-7511141-B2 | Piperidine-piperazine ligands for neurotransmitter receptors | SEPRACOR, INC. (US) | 2009-03-31 | — | — | US | disclosed |
| US-20060063776-A1 | Piperidine-piperazine ligands for neurotransmitter receptors | PERSONS PAUL E | 2006-03-23 | — | — | US | disclosed |
| US-6936614-B2 | Piperidine-piperazine ligands for neurotransmitter receptors | SEPRACOR INC. (US) | 2005-08-30 | — | — | US | disclosed |
| US-20040254195-A1 | Piperidine-piperazine ligands for neurotransmitter receptors | PERSONS PAUL E (US) | 2004-12-16 | — | — | US | disclosed |
| US-6713479-B2 | LIGANDS FOR DOPAMINE, SEROTONIN OR NOREPINEPHRINE RECEPTORS OR TRANSPORTERS | SEPRACOR INC. | 2004-03-30 | — | — | US | disclosed |
| WO-2002069973-A1 | PIPERIDINE-PIPERAZINE LIGAND FOR NEUROTRANSMITTER RECEPTORS | SEPRACOR, INC. (US) | 2002-09-12 | — | — | WO | disclosed |
| US-20020123499-A1 | Piperidine-piperazine ligands for neurotransmitter receptors | SEPRACOR INC. | 2002-09-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063776-A1 | Piperidine-piperazine ligands for neurotransmitter receptors | HTR5A, OPRL1, HTR2A | KDM4E 4061/4885ALDH1A1 888/4885TDP1 1194/4885 |
| US-20020123499-A1 | Piperidine-piperazine ligands for neurotransmitter receptors | HTR5A, OPRL1, HTR2A | KDM4E 4061/4885ALDH1A1 888/4885TDP1 1194/4885 |
| US-20040254195-A1 | Piperidine-piperazine ligands for neurotransmitter receptors | HTR5A, OPRL1, HTR2A | KDM4E 4061/4885ALDH1A1 888/4885TDP1 1194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.