Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 3/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4474016 | 0.88 | NPC1 (0.48) | NPC1RAB9AL3MBTL1NPSR1MEN1 | |
| SCHEMBL4488670 | 0.86 | NPC1 (0.48) | NPC1RAB9AL3MBTL1NPSR1MEN1 | |
| SCHEMBL4486123 | 0.86 | NPC1 (0.48) | NPC1RAB9AL3MBTL1NPSR1MEN1 | |
| SCHEMBL4482242 | 0.85 | NPC1 (0.55) | NPC1RAB9AL3MBTL1NPSR1MEN1 | |
| SCHEMBL30659321 | 0.85 | NPC1 (0.55) | NPC1RAB9AL3MBTL1NPSR1MEN1 | |
| SCHEMBL4491829 | 0.85 | NPC1 (0.46) | NPC1RAB9AL3MBTL1NPSR1MEN1 | |
| SCHEMBL4477843 | 0.82 | SLC2A1 (0.45) | NPC1RAB9AL3MBTL1NPSR1MEN1 | |
| SCHEMBL25734267 | 0.76 | NPC1 (0.49) | NPC1RAB9AL3MBTL1NPSR1MEN1 | |
| SCHEMBL31542297 | 0.76 | NPC1 (0.51) | NPC1RAB9AL3MBTL1NPSR1MEN1 | |
| SCHEMBL16193419 | 0.74 | RAB9A (0.61) | NPC1RAB9AL3MBTL1NPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130123251-A1 | BENZOXAZINE DERIVATIVES AND USES THEREOF | ROCHE PALO ALTO LLC (US) | 2013-05-16 | — | — | US | disclosed |
| US-8377931-B2 | Benzoxazine derivatives and uses thereof | ROCHE PALO ALTO LLC (US) | 2013-02-19 | — | — | US | disclosed |
| US-20090325950-A1 | Benzoxazine derivatives and uses thereof | ROCHE PALO ALTO LLC | 2009-12-31 | — | — | US | disclosed |
| EP-1506179-B1 | BENZOXAZINE DERIVATIVES AS 5-HT6 MODULATORS AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2006-01-25 | — | — | EP | disclosed |
| US-20050130962-A1 | Benzoxazine derivatives and uses thereof | BERGER JACOB (US) | 2005-06-16 | — | — | US | disclosed |
| US-6867204-B2 | Benzoxazine derivatives and uses thereof | ROCHE PALO ALTO LLC (US) | 2005-03-15 | — | — | US | disclosed |
| EP-1506179-A1 | BENZOXAZINE DERIVATIVES AS 5-HT6 MODULATORS AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2005-02-16 | — | — | EP | disclosed |
| US-20030232825-A1 | Benzoxazine derivatives and uses thereof | ROCHE PALO ALTO LLC | 2003-12-18 | — | — | US | disclosed |
| WO-2003095434-A1 | BENZOXAZINE DERIVATIVES AS 5-HT6 MODULATORS AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325950-A1 | Benzoxazine derivatives and uses thereof | F12, CYP4X1, CYP3A5 | NPC1 925/4885RAB9A 921/4885L3MBTL1 3783/4885 |
| US-20050130962-A1 | Benzoxazine derivatives and uses thereof | F12, HAX1, CYP4X1 | NPC1 1016/4885RAB9A 712/4885L3MBTL1 3573/4885 |
| US-20030232825-A1 | Benzoxazine derivatives and uses thereof | CYP3A5, CYP4X1, XDH | NPC1 1347/4885RAB9A 1198/4885L3MBTL1 4670/4885 |
| US-20130123251-A1 | BENZOXAZINE DERIVATIVES AND USES THEREOF | F12, CYP4X1, CYP3A5 | NPC1 925/4885RAB9A 921/4885L3MBTL1 3783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.