Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.55 |
| ▸ | NPC1 | O15118 | 7/20 | 0.55 |
| ▸ | STAT3 | P40763 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4483750 | 0.84 | RAB9A (0.52) | RAB9ANPC1STAT3MAPTGAA | |
| SCHEMBL13294935 | 0.79 | HDAC7 (0.53) | RAB9ANPC1STAT3MAPTGAA | |
| SCHEMBL1003770 | 0.79 | PLK1 (0.54) | RAB9ANPC1MAPTGAAKDM4E | |
| SCHEMBL6829957 | 0.79 | ACHE (0.52) | RAB9ANPC1MAPTGAAKDM4E | |
| SCHEMBL4502457 | 0.78 | NPC1 (0.56) | RAB9ANPC1STAT3MAPTGAA | |
| SCHEMBL4333687 | 0.78 | CTSD (0.67) | RAB9ANPC1MAPTGAAKDM4E | |
| SCHEMBL6739693 | 0.77 | RAB9A (0.50) | RAB9ANPC1STAT3MAPTGAA | |
| SCHEMBL136101 | 0.75 | MAPT (0.60) | RAB9ANPC1MAPTGAAKDM4E | |
| SCHEMBL2479959 | 0.75 | RAB9A (0.48) | RAB9ANPC1MAPTGAAKDM4E | |
| SCHEMBL4527088 | 0.75 | RAB9A (0.57) | RAB9ANPC1STAT3MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009094205-A2 | 3-ARYL-6-ARYL-7H-[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2009-07-30 | — | — | WO | disclosed |