Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.39 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.38 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.38 |
| ▸ | USP1 | O94782 | 1/20 | 0.37 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4073644 | 0.85 | OPRM1 (0.53) | HDAC1HTR1DOPRM1OPRK1OPRD1 | |
| Hydrochloric Acid SCHEMBL4073979 | 0.84 | OPRM1 (0.52) | HDAC1HTR1DOPRM1OPRK1OPRD1 | |
| SCHEMBL4498120 | 0.83 | HDAC1 (0.53) | HDAC1OPRM1OPRK1OPRD1GRIN2D | |
| SCHEMBL4487434 | 0.80 | SMN1; SMN2 (0.50) | HDAC1OPRM1OPRK1OPRD1ADRB1 | |
| SCHEMBL4074968 | 0.80 | OPRM1 (0.60) | HDAC1OPRM1OPRK1OPRD1ADRB1 | |
| SCHEMBL4071701 | 0.79 | OPRM1 (0.47) | HTR1DOPRM1OPRK1OPRD1ADRB1 | |
| SCHEMBL4081861 | 0.78 | OPRM1 (0.53) | HDAC1OPRM1OPRK1OPRD1ADRB1 | |
| SCHEMBL4075641 | 0.75 | OPRM1 (0.52) | HDAC1OPRM1OPRK1OPRD1L3MBTL1 | |
| SCHEMBL4481852 | 0.74 | OPRM1 (0.57) | OPRM1OPRK1OPRD1RARBPDCD1 | |
| Hydrochloric Acid SCHEMBL4475141 | 0.74 | OPRM1 (0.51) | HDAC1OPRM1OPRK1OPRD1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615651-B2 | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof | PFIZER INC. (US) | 2009-11-10 | — | — | US | claimed |