Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | ACP1 | P24666 | 2/20 | 0.54 |
| ▸ | IDH2 | P48735 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 4/20 | 0.48 |
| ▸ | CA1 | P00915 | 4/20 | 0.48 |
| ▸ | CA2 | P00918 | 4/20 | 0.48 |
| ▸ | CA9 | Q16790 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9424651 | 0.85 | CA12 (0.53) | LMNACYP2C9CA12CA1CA2 | |
| SCHEMBL4196236 | 0.82 | LMNA (0.78) | LMNACYP2C9ACP1CA12CA1 | |
| SCHEMBL6297294 | 0.79 | LMNA (0.79) | LMNACYP2C9ACP1CA12CA1 | |
| SCHEMBL13803806 | 0.77 | KEAP1 (0.62) | IDH2CA12CA1CA2CA9 | |
| SCHEMBL4457678 | 0.75 | TP53 (0.73) | LMNACYP2C9ACP1CA12CA1 | |
| SCHEMBL6295746 | 0.75 | CA12 (0.69) | LMNACYP2C9ACP1CA12CA1 | |
| SCHEMBL27885 | 0.75 | LMNA (1.00) | LMNACYP2C9ACP1HPGDCA12 | |
| SCHEMBL5186566 | 0.75 | LMNA (0.72) | LMNACYP2C9ACP1CA12CA1 | |
| SCHEMBL6794200 | 0.75 | HSD11B1 (0.41) | HPGDALDH1A1MAPT | |
| SCHEMBL2789687 | 0.74 | GAA (0.68) | LMNACYP2C9ACP1TP53EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067607-A2 | COMBINATIONS OF PDE4 INHIBITORS AND ANTIPSYCHOTICS FOR THE TREATMENT OF PSYCHOTIC DISORDERS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2009-05-28 | — | — | WO | disclosed |