Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 7/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.37 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | VNN1 | O95497 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | AKT2 | P31751 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20073724 | 0.80 | MEN1 (0.40) | SLC6A2CRBNDDB1GRIN1GRIN2A | |
| SCHEMBL15037442 | 0.77 | OPRM1 (0.45) | CXCR3TSHRALDH1A1OPRM1OPRL1 | |
| SCHEMBL748566 | 0.77 | SLC6A2 (0.39) | SLC6A2CRBNDDB1GRIN1GRIN2A | |
| SCHEMBL1515317 | 0.75 | GRIN1 (0.46) | SLC6A2GRIN1GRIN2AGRIN2BVNN1 | |
| SCHEMBL31584687 | 0.75 | SLC6A2 (0.37) | SLC6A2CRBNDDB1CXCR3GRIN1 | |
| SCHEMBL21989897 | 0.74 | SLC6A2 (0.45) | SLC6A2GRIN1GRIN2AGRIN2BTSHR | |
| SCHEMBL29658709 | 0.74 | SLC6A2 (0.45) | SLC6A2GRIN1GRIN2AGRIN2BTSHR | |
| Hydrochloric Acid SCHEMBL5874289 | 0.74 | SLC6A2 (0.40) | SLC6A2GRIN1GRIN2AGRIN2BTSHR | |
| Hydrochloric Acid SCHEMBL5874197 | 0.74 | SLC6A2 (0.40) | SLC6A2GRIN1GRIN2AGRIN2BTSHR | |
| SCHEMBL4477246 | 0.73 | ALDH1A1 (0.45) | SLC6A2GRIN1GRIN2AGRIN2BTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7494992-B2 | Antiparasitic terpene alkaloids | PFIZER INC. (US) | 2009-02-24 | — | — | US | disclosed |
| US-20070185101-A1 | Antiparasitic terpene alkaloids | PFIZER PRODUCTS INC | 2007-08-09 | — | — | US | disclosed |
| CN-1809576-A | Antiparasitic terpene alkaloids | PFIZER (US) | 2006-07-26 | — | — | CN | disclosed |
| EP-1597264-A2 | ANTIPARASITIC TERPENE ALKALOIDS | Pfizer Limited (GB) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004072086-A2 | ANTIPARASITIC TERPENE ALKALOIDS | PFIZER LIMITED (GB) | 2004-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185101-A1 | Antiparasitic terpene alkaloids | CYP51A1, DHPS, CYP8B1 | SLC6A2 1939/4885CRBN 4774/4885DDB1 3188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.