Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.31 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.31 |
| ▸ | LYN | P07948 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.30 |
| ▸ | TOP2A | P11388 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4482980 | 0.89 | CDK2 (0.35) | CDK2THRBKDM4ECHEK2PLK1 | |
| SCHEMBL4489675 | 0.89 | MAPK14 (0.34) | KDM4ESMN1; SMN2 | |
| SCHEMBL4490917 | 0.80 | BPTF (0.31) | KDM4ELYNTOP2AFGFR1 | |
| SCHEMBL4877540 | 0.80 | TSHR (0.35) | SMN1; SMN2 | |
| SCHEMBL4487540 | 0.80 | FPR1 (0.33) | LYN | |
| SCHEMBL4482133 | 0.78 | MAPK14 (0.35) | KDM4ESMN1; SMN2 | |
| SCHEMBL4482238 | 0.76 | LYN (0.32) | CDK2LYN | |
| SCHEMBL3986813 | 0.73 | TRAP1 (0.37) | KDM4ESMN1; SMN2 | |
| SCHEMBL4486345 | 0.73 | TRAP1 (0.37) | KDM4ESMN1; SMN2 | |
| SCHEMBL4745295 | 0.72 | KDM4E (0.32) | KDM4ELYNTOP2AFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090186907-A1 | Pyrazinones As Cellular Proliferation Inhibitors | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2009-07-23 | — | — | US | claimed |
| US-20090186907-A1 | Pyrazinones As Cellular Proliferation Inhibitors | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2009-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090186907-A1 | Pyrazinones As Cellular Proliferation Inhibitors | MKI67, NR0B1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | CDK2 38/4885THRB 513/4885KDM4E 3719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.