Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 2/20 | 0.33 |
| ▸ | TYMS | P04818 | 2/20 | 0.33 |
| ▸ | PRNP | P04156 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4477996 | 0.88 | TDP1 (0.40) | TDP1POLBALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL4481950 | 0.83 | PTGDR2 (0.42) | TDP1POLBALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL4919985 | 0.74 | SMN1; SMN2 (0.55) | TDP1POLBALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL4493748 | 0.74 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2MAPTCYP2C9NPSR1 | |
| SCHEMBL10571444 | 0.73 | NR1H2 (0.39) | TDP1POLBL3MBTL1MAPTDHFR | |
| SCHEMBL11588944 | 0.73 | MAPT (0.43) | TDP1POLBALDH1A1L3MBTL1MAPT | |
| SCHEMBL3077683 | 0.71 | SMN1; SMN2 (0.56) | POLBALDH1A1SMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL11586890 | 0.70 | PPARG (0.42) | TDP1POLBALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL11589506 | 0.68 | POLB (0.44) | TDP1POLBALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL13043591 | 0.68 | TDP1 (0.41) | TDP1SMN1; SMN2L3MBTL1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7557123-B2 | Heterocyclic compound and medicinal use thereof | KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2009-07-07 | — | — | US | disclosed |
| US-20040220215-A1 | Novel heterocyclic compound and medicinal use thereof | KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2004-11-04 | — | — | US | disclosed |
| EP-1403253-A1 | NOVEL HETEROCYCLIC COMPOUND AND MEDICINAL USE THEREOF | Kyoto Pharmaceutical Industries, Ltd. (JP) | 2004-03-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040220215-A1 | Novel heterocyclic compound and medicinal use thereof | GPR119, INSR, GLP1R | TDP1 3937/4885POLB 3675/4885ALDH1A1 1837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.