Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 1.00 |
| ▸ | NPC1 | O15118 | 5/20 | 0.78 |
| ▸ | RAB9A | P51151 | 4/20 | 0.78 |
| ▸ | MAPT | P10636 | 4/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.68 |
| ▸ | TP53 | P04637 | 3/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | GFER | P55789 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 5/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28542524 | 0.98 | LOXL2 (0.96) | LOXL2NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL10796782 | 0.89 | LOXL2 (0.80) | LOXL2NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL155002 | 0.88 | MAPT (1.00) | LOXL2NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL8424117 | 0.86 | LOXL2 (0.75) | LOXL2NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL1786789 | 0.84 | LOXL2 (0.72) | LOXL2NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL11399187 | 0.84 | MAPT (0.84) | LOXL2NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL9642061 | 0.84 | MAPT (0.84) | LOXL2NPC1RAB9AMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL242283 | 0.82 | LOXL2 (0.70) | LOXL2NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL2123399 | 0.81 | MAPT (0.78) | LOXL2NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL31276791 | 0.81 | MAPT (0.78) | LOXL2NPC1RAB9AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7534804-B2 | Benzoxazole inhibitors of 15-lipoxygenase | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-05-19 | — | — | US | claimed |
| US-20070049628-A1 | Benzoxazole inhibitors of 15-lipoxygenase | BRISTOL-MYERS SQUIBB COMPANY | 2007-03-01 | — | — | US | claimed |
| US-20240208992-A1 | MACROCYCLES AS CFTR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2024-06-27 | — | — | US | disclosed |
| WO-2018048930-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | disclosed |
| WO-2018048930-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | disclosed |
| US-20160244464-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. | 2016-08-25 | — | — | US | disclosed |
| US-20160031907-A1 | Substituted Benzene Compounds | Epizyme, Inc. | 2016-02-04 | — | — | US | disclosed |
| US-9243001-B2 | Substituted benzene compounds | Epizyme, Inc. (US) | 2016-01-26 | — | — | US | disclosed |
| EP-2970281-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014172044-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2014-10-23 | — | — | WO | disclosed |
| US-20140315945-A1 | Substituted Benzene Compounds | Epizyme, Inc. (US) | 2014-10-23 | — | — | US | disclosed |
| US-7534804-B2 | Benzoxazole inhibitors of 15-lipoxygenase | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-05-19 | — | — | US | disclosed |
| CN-101287718-A | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER PROD INC (US) | 2008-10-15 | — | — | CN | disclosed |
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PFIZER INC. | 2008-04-17 | — | — | US | disclosed |
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PFIZER INC. | 2008-04-17 | — | — | US | disclosed |
| US-20070049628-A1 | Benzoxazole inhibitors of 15-lipoxygenase | BRISTOL-MYERS SQUIBB COMPANY | 2007-03-01 | — | — | US | disclosed |
| US-20060229363-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | HAMANAKA ERNEST S | 2006-10-12 | — | — | US | disclosed |
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER INC | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060229363-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | PPARA, PPARG, PPARD | LOXL2 3046/4885NPC1 50/4885RAB9A 2581/4885 |
| US-20070049628-A1 | Benzoxazole inhibitors of 15-lipoxygenase | ALOX15, ALOX5, ALOX15B | LOXL2 11/4885NPC1 1288/4885RAB9A 4142/4885 |
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PPARA, PPARG, PPARD | LOXL2 3123/4885NPC1 59/4885RAB9A 2271/4885 |
| US-20160031907-A1 | Substituted Benzene Compounds | CYP1B1, CYP4B1, CYP2B6 | LOXL2 2169/4885NPC1 841/4885RAB9A 3815/4885 |
| US-20240208992-A1 | MACROCYCLES AS CFTR MODULATORS | CFTR, PKD1, ARRB1 | LOXL2 4518/4885NPC1 239/4885RAB9A 1728/4885 |
| US-20140315945-A1 | Substituted Benzene Compounds | VHL, AHR, TP53 | LOXL2 3500/4885NPC1 1399/4885RAB9A 4520/4885 |
| US-20160244464-A1 | SUBSTITUTED BENZENE COMPOUNDS | VHL, AHR, TP53 | LOXL2 3500/4885NPC1 1399/4885RAB9A 4520/4885 |
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PPARA, PPARG, PPARD | LOXL2 3123/4885NPC1 59/4885RAB9A 2271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.