SCHEMBL448336

SCHEMBL448336

COc1c(F)c(F)cc(F)c1F

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.39
TUBB1 Q9H4B7 2/20 0.38
TDP1 Q9NUW8 1/20 0.36
ACHE P22303 1/20 0.36
HSD17B10 Q99714 1/20 0.35
CYP3A4 P08684 1/20 0.35
MAPT P10636 1/20 0.35
CA9 Q16790 1/20 0.35
CA2 P00918 4/20 0.33
CA1 P00915 3/20 0.33
CA4 P22748 3/20 0.33
CA12 O43570 1/20 0.33
CA7 P43166 1/20 0.33
CA13 Q8N1Q1 1/20 0.33
HTR2A P28223 1/20 0.33
HTR2C P28335 1/20 0.33
HTR2B P41595 1/20 0.33
KDM4E B2RXH2 1/20 0.33
MAPK1 P28482 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7976367 0.85 TUBB1 (0.41) ALDH1A1TUBB1ACHECYP3A4MAPT
SCHEMBL1099372 0.85 ACHE (0.36) ALDH1A1TUBB1TDP1ACHEHSD17B10
SCHEMBL16256381 0.85 ACHE (0.36) ALDH1A1TUBB1TDP1ACHECYP3A4
SCHEMBL6739577 0.83 TUBB1 (0.35) ALDH1A1TUBB1TDP1ACHEHSD17B10
SCHEMBL2036050 0.83 TDP1 (0.44) ALDH1A1TUBB1TDP1CYP3A4MAPT
SCHEMBL31210105 0.83 TUBB1 (0.32) ALDH1A1TUBB1TDP1ACHEHSD17B10
SCHEMBL9149201 0.83 HSD17B10 (0.38) ALDH1A1TUBB1TDP1ACHEHSD17B10
SCHEMBL1099369 0.83 TUBB1 (0.32) ALDH1A1TUBB1TDP1ACHEHSD17B10
SCHEMBL31015964 0.83 CA2 (0.41) ALDH1A1TUBB1HSD17B10CA2CA1
SCHEMBL135396 0.83 TUBB1 (0.32) ALDH1A1TUBB1TDP1ACHEHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 166 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117466717-A Fully substituted alkyl alkenyl ether, preparation method and application 四川大学 2024-01-30 CN claimed
CN-116162236-A Preparation method of branched polyaryletherketone resin, branched polyaryletherketone resin and application of branched polyaryletherketone resin in gas separation membrane 中国科学院大连化学物理研究所 2023-05-26 CN claimed
US-11063297-B2 Electrochemical cell and electrolyte for same Viking Power Systems Pte, Ltd. (SG) 2021-07-13 US claimed
CN-112490015-A Asymmetric high-voltage super capacitor 西安合容新能源科技有限公司 2021-03-12 CN claimed
CN-107681197-B Electrolyte for lithium-sulfur battery 西安科技大学 2020-02-14 CN claimed
US-20190198932-A1 ELECTROCHEMICAL CELL AND ELECTROLYTE FOR SAME PELLION TECHNOLOGIES INC. (US) 2019-06-27 US claimed
US-20190198933-A1 ELECTROCHEMICAL CELL AND ELECTROLYTE FOR SAME PELLION TECHNOLOGIES INC. (US) 2019-06-27 US claimed
CN-104478669-A Asymmetric terphenyl liquid crystal compound UNIV SHIHEZI 2015-04-01 CN claimed
US-8952083-B2 Fluorocopolymer composition and its production process ASAHI GLASS COMPANY, LIMITED (JP) 2015-02-10 US claimed
US-12637438-B2 Protoporphyrinogen oxidase inhibitors ENKO CHEM, INC. (US) 2026-05-26 US disclosed
CN-119859091-A Synthesis method of indene alkyl substituted polyfluoroaromatic hydrocarbon 南通大学 2025-04-22 CN disclosed
US-20250084044-A1 PROTOPORPHYRINOGEN OXIDASE INHIBITORS ENKO CHEM, INC. (US) 2025-03-13 US disclosed
EP-4462999-A1 PROTOPORPHYRINOGEN OXIDASE INHIBITORS Enko Chem, Inc. (US) 2024-11-20 EP disclosed
CN-118541030-A Protoporphyrinogen oxidase inhibitors 恩科化学公司 2024-08-23 CN disclosed
CN-1229791-A Ester compounds SUMITOMO CHEMICAL CO (JP) 1999-09-29 CN disclosed
EP-0851524-A1 Non-aqueous electrolyte secondary cell SONY CORPORATION (JP) 1998-07-01 EP disclosed
CN-1180705-A Method for producing [ fluoroaryl ] boron compound and method for producing tetrakis [ fluoroaryl ] boron derivative NIPPON CATALYTIC CHEM IND (JP) 1998-05-06 CN disclosed
EP-0838466-A2 Producing process of (fluoroaryl) borane compound and producing process of tetrakis (fluoroaryl) borate derivative NIPPON SHOKUBAI CO., LTD. (JP) 1998-04-29 EP disclosed
EP-0825195-A1 PROCESS FOR THE PREPARATION OF FLUORINATED ARYLMAGNESIUM DERIVATIVES AND PROCESS FOR THE PREPARATION OF (FLUORINATED ARYL)BORON COMPOUNDS NIPPON SHOKUBAI CO., LTD. (JP) 1998-02-25 EP disclosed
EP-0778264-A1 Tertiary amines having antimycotic and cholesterol lowering activity F. HOFFMANN-LA ROCHE AG (CH) 1997-06-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250084044-A1 PROTOPORPHYRINOGEN OXIDASE INHIBITORS PPOX, CYP4X1, PNPO ALDH1A1 1008/4885TUBB1 644/4885TDP1 862/4885
US-12637438-B2 Protoporphyrinogen oxidase inhibitors PPOX, CYP4X1, CBR3 ALDH1A1 741/4885TUBB1 1033/4885TDP1 2308/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.