Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | NTSR1 | P30989 | 3/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KRAS | P01116 | 2/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9200019 | 0.79 | MTNR1A (0.60) | ATMKDM4EALDH1A1HDAC8HDAC6 | |
| SCHEMBL19674140 | 0.79 | ATM (0.57) | ATMKDM4EALDH1A1NTSR1HDAC8 | |
| SCHEMBL5449877 | 0.79 | ATM (0.57) | ATMKDM4EALDH1A1NTSR1HDAC8 | |
| SCHEMBL27616328 | 0.79 | NTSR1 (0.41) | NTSR1HDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL5637363 | 0.78 | ATM (0.56) | ATMKDM4EALDH1A1NTSR1HDAC8 | |
| SCHEMBL21810428 | 0.78 | NTSR1 (0.57) | ATMNTSR1HDAC8HDAC6HDAC3 | |
| SCHEMBL14876504 | 0.78 | NTSR1 (0.57) | ATMKDM4EALDH1A1NTSR1HDAC8 | |
| SCHEMBL6029964 | 0.77 | ATM (0.58) | ATMKDM4EALDH1A1NTSR1HDAC8 | |
| SCHEMBL14594510 | 0.77 | ATM (0.55) | ATMKDM4EALDH1A1HDAC8HDAC6 | |
| SCHEMBL4820329 | 0.76 | NTSR1 (0.47) | NTSR1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7566791-B2 | Substituted 3-carbonyl-1h-indol-1yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) | WYETH (US) | 2009-07-28 | — | — | US | disclosed |
| US-20060178412-A1 | Substituted 3-carbonyl-1h-indol-1-yl acetic acid derivatives as ibhibitors of plasminogen activator inhibitor-1 (PAI-1) | WYETH (US) | 2006-08-10 | — | — | US | disclosed |
| US-7078429-B2 | Substituted 3-carbonyl-1H-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) | WYETH (US) | 2006-07-18 | — | — | US | disclosed |
| EP-1569900-B1 | SUBSTITUTED 3-CARBONYL-1-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) | WYETH CORP (US) | 2006-06-28 | — | — | EP | disclosed |
| EP-1569900-A2 | SUBSTITUTED 3-CARBONYL-1-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) | Wyeth (US) | 2005-09-07 | — | — | EP | disclosed |
| US-20040122070-A1 | Substituted 3-carbonyl-1H-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) | WYETH | 2004-06-24 | — | — | US | disclosed |
| WO-2004052855-A2 | SUBSTITUTED 3-CARBONYL-1H-INDOL-1-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) | WYETH (US) | 2004-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040122070-A1 | Substituted 3-carbonyl-1H-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) | SERPINE1, PLAT, SERPINC1 | ATM 2448/4885KDM4E 3306/4885ALDH1A1 63/4885 |
| US-20060178412-A1 | Substituted 3-carbonyl-1h-indol-1-yl acetic acid derivatives as ibhibitors of plasminogen activator inhibitor-1 (PAI-1) | SERPINE1, PLAT, TFPI | ATM 1881/4885KDM4E 3283/4885ALDH1A1 42/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.