Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.36 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.32 |
| ▸ | HTR3B | O95264 | 1/20 | 0.32 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.32 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28507681 | 0.74 | KDM4E (0.47) | ALDH1A1MAP3K14ROCK1CDC7CDK2 | |
| SCHEMBL1404632 | 0.74 | ENPP2 (0.38) | ALDH1A1ENPP2 | |
| SCHEMBL28668509 | 0.74 | ENPP2 (0.38) | ALDH1A1ENPP2CDC7CDK2LMNA | |
| SCHEMBL1843835 | 0.73 | UHRF1 (0.50) | ALDH1A1L3MBTL1ROCK1LMNASMN1; SMN2 | |
| SCHEMBL17181769 | 0.73 | ASIC3 (0.41) | NR4A2ALDH1A1MAPTENPP2KDM4C | |
| SCHEMBL29952078 | 0.73 | UHRF1 (0.50) | ALDH1A1L3MBTL1ROCK1LMNASMN1; SMN2 | |
| SCHEMBL29954387 | 0.73 | KMO (0.34) | ALDH1A1KDM4CROCK1CDC7CDK2 | |
| SCHEMBL1843516 | 0.73 | KMO (0.34) | ALDH1A1KDM4CROCK1CDC7CDK2 | |
| SCHEMBL29798588 | 0.69 | — | — | |
| SCHEMBL135549 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| US-7615639-B2 | 1-pyridyl-benzofuro[3,2-b]pyridin-2(1H)-ones | TIBOTEC PHARMACEUTICALS, LTD. (IE) | 2009-11-10 | — | — | US | disclosed |
| US-20070265295-A1 | 1-Heterocyclyl-1,5-Dihydro-Pyrido[3,2-B]Indol-2-Ones | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2007-11-15 | — | — | US | disclosed |
| EP-1758911-A1 | 1-HETEROCYCLYL-1,5-DIHYDRO-PYRIDO[3,2-B]INDOL-2-ONES | Tibotec Pharmaceuticals Ltd. (IE) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005111047-A1 | 1-HETEROCYCLYL-1,5-DIHYDRO-PYRIDO[3,2-B]INDOL-2-ONES | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2005-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070265295-A1 | 1-Heterocyclyl-1,5-Dihydro-Pyrido[3,2-B]Indol-2-Ones | CBR1, HRH4, CYP4B1 | NR4A2 17/4885ALDH1A1 984/4885MAPT 4870/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.