Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 3/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD1 | P21728 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2324209 | 0.82 | LTA4H (0.61) | SMN1; SMN2KDM4EESR1ESR2TDP1 | |
| SCHEMBL2321215 | 0.82 | SMN1; SMN2 (0.57) | SMN1; SMN2KDM4EESR1ESR2TDP1 | |
| SCHEMBL4477326 | 0.81 | LTA4H (0.62) | SMN1; SMN2KDM4ETDP1LTA4H | |
| SCHEMBL4485184 | 0.79 | SMN1; SMN2 (0.49) | SMN1; SMN2KDM4ETDP1MEN1KMT2A | |
| SCHEMBL3564031 | 0.79 | LTA4H (0.49) | SMN1; SMN2KDM4EESR1ESR2TDP1 | |
| SCHEMBL4524330 | 0.79 | SMN1; SMN2 (0.49) | SMN1; SMN2KDM4ETDP1MEN1KMT2A | |
| SCHEMBL4465080 | 0.79 | SMN1; SMN2 (0.52) | SMN1; SMN2KDM4ETDP1MEN1KMT2A | |
| SCHEMBL3564150 | 0.78 | ALDH1A1 (0.49) | SMN1; SMN2KDM4EESR1ESR2TDP1 | |
| SCHEMBL6962455 | 0.78 | LTA4H (0.62) | SMN1; SMN2KDM4ETDP1LTA4H | |
| SCHEMBL4520307 | 0.78 | CYP1A2 (0.51) | SMN1; SMN2KDM4ETDP1TSHRLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7592358-B2 | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-09-22 | — | — | US | disclosed |
| US-20050234101-A1 | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234101-A1 | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds | MCHR1, GPR119, MCHR2 | SMN1; SMN2 2309/4885KDM4E 2256/4885ESR1 1626/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.