Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ODC1 | P11926 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.32 |
| ▸ | FDPS | P14324 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19461382 | 1.00 | ODC1 (0.35) | ODC1KDM4ELMNAMAPTRAB9A | |
| SCHEMBL625789 | 0.95 | FDPS (0.33) | ODC1NAALAD2FDPS | |
| SCHEMBL1487659 | 0.95 | FDPS (0.33) | ODC1NAALAD2FDPS | |
| SCHEMBL10912285 | 0.73 | ODC1 (0.42) | ODC1KDM4ELMNAMAPTRAB9A | |
| SCHEMBL27905222 | 0.72 | ODC1 (0.46) | ODC1KDM4ELMNAMAPTRAB9A | |
| SCHEMBL6567609 | 0.68 | ODC1 (0.37) | ODC1KDM4ELMNAMAPTRAB9A | |
| SCHEMBL10659088 | 0.68 | ODC1 (0.37) | ODC1KDM4ELMNAMAPTRAB9A | |
| SCHEMBL7924611 | 0.68 | ODC1 (0.37) | ODC1KDM4ELMNAMAPTRAB9A | |
| SCHEMBL2823239 | 0.68 | ODC1 (0.37) | ODC1KDM4ELMNAMAPTRAB9A | |
| SCHEMBL30410707 | 0.66 | NAALAD2 (0.47) | ODC1KDM4ELMNAMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114428-A2 | TRIAZOLE MACROCYCLE SYSTEMS | Aileron Therapeutics, Inc. (US) | 2009-11-11 | — | — | EP | claimed |
| WO-2008104000-A2 | TRIAZOLE MACROCYCLE SYSTEMS | AILERON THERAPEUTICS, INC. (US) | 2008-08-28 | — | — | WO | claimed |