Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 5/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4472494 | 0.85 | ALDH1A1 (0.38) | KDRCYP3A4ALDH1A1PDGFRBHPGD | |
| SCHEMBL4479411 | 0.84 | MAP3K11 (0.48) | NTRK1CYP3A4ALDH1A1CLK1DYRK1A | |
| SCHEMBL4490967 | 0.83 | NPC1 (0.54) | KDRNTRK1CYP3A4ALDH1A1PDGFRB | |
| SCHEMBL4481644 | 0.83 | KDR (0.43) | KDRCYP3A4PDGFRBMAPTRAB9A | |
| SCHEMBL4482796 | 0.83 | KDR (0.53) | KDRALDH1A1PDGFRBSMN1; SMN2RAB9A | |
| SCHEMBL4470895 | 0.83 | DYRK1A (0.48) | CYP3A4ALDH1A1HPGDDYRK1ADYRK1B | |
| SCHEMBL4475436 | 0.83 | GSK3B (0.46) | KDRALDH1A1HPGDDYRK1ADYRK1B | |
| SCHEMBL4491792 | 0.82 | MEN1 (0.57) | PKMKDRPDGFRBMAPTRAB9A | |
| SCHEMBL4472148 | 0.82 | IDO1 (0.46) | KDRALDH1A1PDGFRBHTTSMN1; SMN2 | |
| SCHEMBL4485740 | 0.80 | CAMKK2 (0.35) | KDRNTRK1CYP3A4CLK1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7592365-B2 | Substituted pyrroles, compositions containing same, method for making same and use thereof | AVENTIS PHARMA S.A. (FR) | 2009-09-22 | — | — | US | disclosed |
| EP-1851198-B1 | SUBSTITUTED PYRROLES, COMPOSITIONS CONTAINING SAME, METHOD FOR MAKING SAME AND USE THEREOF | AVENTIS PHARMA SA (FR) | 2008-12-31 | — | — | EP | disclosed |
| US-20080167368-A1 | Substituted Pyrroles, Compositions Containing Same, Method for Making Same and Use Thereof | AVENTIS PHARMA S.A. (FR) | 2008-07-10 | — | — | US | disclosed |
| CN-101115716-A | Substituted pyrroles, compositions containing same, method for making same and use thereof | AVENTIS PHARMA SA (FR) | 2008-01-30 | — | — | CN | disclosed |
| EP-1851198-A1 | SUBSTITUTED PYRROLES, COMPOSITIONS CONTAINING SAME, METHOD FOR MAKING SAME AND USE THEREOF | Aventis Pharma S.A. (FR) | 2007-11-07 | — | — | EP | disclosed |
| WO-2006084996-A1 | SUBSTITUTED PYRROLES, COMPOSITIONS CONTAINING SAME, METHOD FOR MAKING SAME AND USE THEREOF | AVENTIS PHARMA S.A. (FR) | 2006-08-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167368-A1 | Substituted Pyrroles, Compositions Containing Same, Method for Making Same and Use Thereof | PRMT1, ADPRS, RRM2B | PKM 2760/4885CYP2C19 2642/4885KDR 2379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.