SCHEMBL4486310

SCHEMBL4486310

CC(C)(C)c1ccc2c(c1)Cc1cc(C(C)(C)C)cc(-c3ccccc3)c1-2

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.42
ALDH1A1 P00352 1/20 0.42
PLA2G1B P04054 1/20 0.42
NFKB1 P19838 1/20 0.42
CASP3 P42574 1/20 0.42
RAB9A P51151 1/20 0.42
NFKB2 Q00653 1/20 0.42
RELA Q04206 1/20 0.42
SENP8 Q96LD8 1/20 0.42
SENP7 Q9BQF6 1/20 0.42
SENP6 Q9GZR1 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
ATG4B Q9Y4P1 1/20 0.42
KIF11 P52732 1/20 0.35
CYP19A1 P11511 1/20 0.35
ELANE P08246 1/20 0.34
CD69 Q07108 1/20 0.34
GPR84 Q9NQS5 1/20 0.33
CNR1 P21554 2/20 0.33
CNR2 P34972 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5820049 0.91 KIF11 (0.38) NPC1ALDH1A1PLA2G1BNFKB1CASP3
SCHEMBL15457989 0.86 ALDH1A1 (0.34) NPC1ALDH1A1PLA2G1BNFKB1CASP3
SCHEMBL4557939 0.79 NPC1 (0.35) NPC1ALDH1A1PLA2G1BNFKB1CASP3
SCHEMBL5437344 0.79 ALDH1A1 (0.37) NPC1ALDH1A1PLA2G1BNFKB1CASP3
SCHEMBL28556632 0.77 KIF11 (0.42) NPC1ALDH1A1PLA2G1BNFKB1CASP3
SCHEMBL27989925 0.77 NPC1 (0.40) NPC1ALDH1A1PLA2G1BNFKB1CASP3
SCHEMBL30430052 0.76 ALDH1A1 (0.35) NPC1ALDH1A1PLA2G1BNFKB1CASP3
SCHEMBL25633605 0.76 ELANE (0.36) NPC1ALDH1A1PLA2G1BNFKB1CASP3
SCHEMBL5820431 0.76 ALDH1A1 (0.35) NPC1ALDH1A1PLA2G1BNFKB1CASP3
SCHEMBL3888554 0.76 ALDH1A1 (0.35) NPC1ALDH1A1PLA2G1BNFKB1CASP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2046842-A2 ISOTACTIC-ATACTIC POLYPROPYLENE AND METHODS OF MAKING SAME Fina Technology, Inc. (US) 2009-04-15 EP disclosed
US-7470759-B2 Isotactic-atactic polypropylene and methods of making same FINA TECHNOLOGY, INC. (US) 2008-12-30 US disclosed
WO-2008016904-A2 ISOTACTIC-ATACTIC POLYPROPYLENE AND METHODS OF MAKING SAME FINA TECHNOLOGY, INC. (US) 2008-02-07 WO disclosed
US-20080027193-A1 ISOTACTIC-ATACTIC POLYPROPYLENE AND METHODS OF MAKING SAME FINA TECHNOLOGY, INC. (US) 2008-01-31 US disclosed
WO-2006137818-A1 CATALYST COMPONENTS AND THEIR USE IN THE POLYMERIZATION OF OLEFINS FINA TECHNOLOGY, INC. (US) 2006-12-28 WO disclosed
US-20050148460-A1 Catalyst components and their use in the polymerization of olefins FINA TECHNOLOGY, INC. 2005-07-07 US disclosed
US-6346635-B1 FORMING A COMPLEX, DEPROTINATION, SILATION AND COMPLEXING BASELL POLYOLEFINE GMBH (DE) 2002-02-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050148460-A1 Catalyst components and their use in the polymerization of olefins NPY5R, SSTR5, FGR NPC1 3753/4885ALDH1A1 4091/4885PLA2G1B 4304/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.