Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL443847 | 0.98 | — | — | |
| Hydrochloric Acid SCHEMBL445664 | 0.95 | — | — | |
| Hydrochloric Acid SCHEMBL27979200 | 0.95 | EGLN3 (0.41) | — | |
| Hydrochloric Acid SCHEMBL446819 | 0.95 | ALDH1A1 (0.39) | — | |
| SCHEMBL28260322 | 0.89 | ALDH1A1 (0.35) | — | |
| Isopropyl Alcohol SCHEMBL17780187 | 0.87 | TBXAS1 (0.35) | — | |
| Naphthalene SCHEMBL7446184 | 0.84 | FAAH (0.42) | — | |
| Glutarate SCHEMBL30490438 | 0.82 | TBXAS1 (0.51) | — | |
| Trifluoromethanesulfonic Acid SCHEMBL22635812 | 0.81 | L3MBTL1 (0.32) | — | |
| SCHEMBL28002921 | 0.78 | HTT (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3027610-A1 | UREA COMPOUNDS AND THEIR USE AS FAAH ENZYME INHIBITORS | BIAL - Portela & Cª S.A. (PT) | 2016-06-08 | — | — | EP | disclosed |
| US-9353082-B2 | Pharmaceutical compounds | BIAL—PORTELA & CA, S.A. (PT) | 2016-05-31 | — | — | US | disclosed |
| WO-2015016728-A1 | UREA COMPOUNDS AND THEIR USE AS FAAH ENZYME INHIBITORS | BIAL - PORTELA & Cª, S.A. (PT) | 2015-02-05 | — | — | WO | disclosed |
| WO-2015016729-A1 | UREA COMPOUNDS AND THEIR USE AS FAAH ENZYME INHIBITORS | BIAL - PORTELA & Cª, S.A. (PT) | 2015-02-05 | — | — | WO | disclosed |
| US-20120065191-A1 | PHARMACEUTICAL COMPOUNDS | BIAL - PORTELA & Cª, S.A. (PT) | 2012-03-15 | — | — | US | disclosed |
| WO-2001042224-A1 | CARBOXYAMIDO DERIVATIVES | MITSUBISHI PHARMA CORPORATION (JP) | 2001-06-14 | — | — | WO | disclosed |