Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 20/20 | 0.55 |
| ▸ | SLC6A2 known ✓ | P23975 | 16/20 | 0.55 |
| ▸ | SLC6A3 known ✓ | Q01959 | 9/20 | 0.49 |
| ▸ | KCNH2 known ✓ | Q12809 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL4489256 | 1.00 | SLC6A4 (0.55) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| Fumaric Acid SCHEMBL4494206 | 0.93 | SLC6A4 (0.62) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| Fumaric Acid SCHEMBL4494204 | 0.93 | SLC6A4 (0.62) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL4491706 | 0.90 | SLC6A4 (0.58) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| Fumaric Acid SCHEMBL4494094 | 0.84 | SLC6A4 (0.62) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| Fumaric Acid SCHEMBL4494095 | 0.84 | SLC6A4 (0.62) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| Fumaric Acid SCHEMBL4482379 | 0.83 | SLC6A4 (0.50) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| Fumaric Acid SCHEMBL4482376 | 0.83 | SLC6A4 (0.50) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL4484028 | 0.81 | SLC6A4 (0.57) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| Fumaric Acid SCHEMBL4485500 | 0.80 | SLC6A2 (0.61) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7619096-B2 | 3-Aminopyrrolidines as inhibitors of monoamine uptake | ELI LILLY AND COMPANY (US) | 2009-11-17 | — | — | US | disclosed |
| EP-1638934-B1 | 3-AMINOPYRROLIDINES AS INHIBITORS OF MONOAMINE UPTAKE | LILLY CO ELI (US) | 2008-01-09 | — | — | EP | disclosed |
| US-20060270713-A1 | 3-Aminopyrrolidines as inhibitors of monoamine uptake | ELI LILLY AND COMPANY | 2006-11-30 | — | — | US | disclosed |
| EP-1638934-A1 | 3-AMINOPYRROLIDINES AS INHIBITORS OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2006-03-29 | — | — | EP | disclosed |
| WO-2005000811-A1 | 3-AMINOPYRROLIDINES AS INHIBITORS OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2005-01-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060270713-A1 | 3-Aminopyrrolidines as inhibitors of monoamine uptake | SLC6A2, SLC6A3, SLC18A2 | SLC6A4 5/4885SLC6A2 1/4885SLC6A3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.