Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 4/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4485862 | 1.00 | KDM4E (0.48) | KDM4EALDH1A1CHEK2OPRM1OPRD1 | |
| SCHEMBL4501428 | 1.00 | KDM4E (0.48) | KDM4EALDH1A1CHEK2OPRM1OPRD1 | |
| SCHEMBL4078567 | 0.88 | KDM4E (0.46) | KDM4EALDH1A1CHEK2OPRM1OPRD1 | |
| SCHEMBL4084233 | 0.82 | OPRM1 (0.57) | OPRM1OPRD1OPRK1MAOAHDAC1 | |
| SCHEMBL4075498 | 0.77 | OPRM1 (0.43) | OPRM1OPRD1OPRK1PDE4APDE4B | |
| SCHEMBL4487434 | 0.76 | SMN1; SMN2 (0.50) | ALDH1A1OPRM1OPRD1OPRK1HDAC1 | |
| SCHEMBL6253167 | 0.75 | KDM4E (0.55) | KDM4EALDH1A1TAS1R3TAS1R1PRMT5 | |
| SCHEMBL4478715 | 0.73 | OPRM1 (0.64) | OPRM1OPRD1OPRK1MAOAMAOB | |
| SCHEMBL4073259 | 0.73 | MEN1 (0.41) | ALDH1A1OPRM1OPRD1OPRK1 | |
| SCHEMBL4071701 | 0.72 | OPRM1 (0.47) | OPRM1OPRD1OPRK1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615651-B2 | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof | PFIZER INC. (US) | 2009-11-10 | — | — | US | claimed |