Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 8/20 | 0.39 |
| ▸ | DRD4 | P21917 | 8/20 | 0.39 |
| ▸ | DRD3 | P35462 | 8/20 | 0.39 |
| ▸ | DRD1 | P21728 | 2/20 | 0.39 |
| ▸ | DRD5 | P21918 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4075498 | 0.86 | OPRM1 (0.43) | HTR1DOPRM1OPRD1OPRK1 | |
| SCHEMBL4487434 | 0.79 | SMN1; SMN2 (0.50) | ALDH1A1OPRM1OPRD1OPRK1 | |
| SCHEMBL4084233 | 0.79 | OPRM1 (0.57) | HTR1DOPRM1OPRD1OPRK1 | |
| SCHEMBL4074968 | 0.74 | OPRM1 (0.60) | MEN1KMT2AALDH1A1OPRM1OPRD1 | |
| SCHEMBL8035957 | 0.73 | DRD2 (0.53) | ALDH1A1DRD2DRD4DRD3DRD1 | |
| SCHEMBL4071701 | 0.73 | OPRM1 (0.47) | HTR1DOPRM1OPRD1OPRK1 | |
| SCHEMBL4485862 | 0.73 | KDM4E (0.48) | ALDH1A1OPRM1OPRD1OPRK1 | |
| SCHEMBL4501428 | 0.73 | KDM4E (0.48) | ALDH1A1OPRM1OPRD1OPRK1 | |
| SCHEMBL4490082 | 0.73 | KDM4E (0.48) | ALDH1A1OPRM1OPRD1OPRK1 | |
| SCHEMBL4073993 | 0.72 | SCN3A (0.42) | MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615651-B2 | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof | PFIZER INC. (US) | 2009-11-10 | — | — | US | claimed |
| EP-2084127-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | Pfizer Products Inc. (US) | 2009-08-05 | — | — | EP | claimed |
| WO-2008059335-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | PFIZER PRODUCTS INC. (US) | 2008-05-22 | — | — | WO | claimed |