Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.36 |
| ▸ | OXTR | P30559 | 1/20 | 0.36 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4073259 | 0.86 | MEN1 (0.41) | OPRM1OPRD1OPRK1HTR1D | |
| SCHEMBL4084233 | 0.86 | OPRM1 (0.57) | OPRM1OPRD1OPRK1HTR1DHDAC1 | |
| SCHEMBL4487434 | 0.84 | SMN1; SMN2 (0.50) | OPRM1OPRD1OPRK1HDAC1RARB | |
| SCHEMBL4071701 | 0.80 | OPRM1 (0.47) | OPRM1OPRD1OPRK1HTR1DRARB | |
| SCHEMBL4074968 | 0.79 | OPRM1 (0.60) | OPRM1OPRD1OPRK1HDAC1RARB | |
| SCHEMBL4501428 | 0.77 | KDM4E (0.48) | OPRM1OPRD1OPRK1HDAC1PDE4A | |
| SCHEMBL4490082 | 0.77 | KDM4E (0.48) | OPRM1OPRD1OPRK1HDAC1PDE4A | |
| SCHEMBL4485862 | 0.77 | KDM4E (0.48) | OPRM1OPRD1OPRK1HDAC1PDE4A | |
| SCHEMBL4073993 | 0.77 | SCN3A (0.42) | HDAC1RARB | |
| SCHEMBL4081861 | 0.77 | OPRM1 (0.53) | OPRM1OPRD1OPRK1HDAC1PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615651-B2 | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof | PFIZER INC. (US) | 2009-11-10 | — | — | US | claimed |
| EP-2084127-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | Pfizer Products Inc. (US) | 2009-08-05 | — | — | EP | claimed |
| WO-2008059335-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | PFIZER PRODUCTS INC. (US) | 2008-05-22 | — | — | WO | claimed |