Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 11/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 10/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 8/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | SMO | Q99835 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4074327 | 0.87 | OPRM1 (0.56) | OPRK1OPRM1OPRD1HDAC1PRMT5 | |
| SCHEMBL4485653 | 0.87 | OPRM1 (0.57) | OPRK1OPRM1OPRD1HDAC1TMEM97 | |
| SCHEMBL12608179 | 0.86 | OPRM1 (0.50) | OPRK1OPRM1OPRD1HDAC1MAP4K1 | |
| Hydrochloric Acid SCHEMBL16194744 | 0.85 | OPRM1 (0.49) | OPRK1OPRM1OPRD1HDAC1MAP4K1 | |
| SCHEMBL4480489 | 0.84 | OPRM1 (0.52) | OPRK1OPRM1OPRD1HDAC1PRMT5 | |
| SCHEMBL4478715 | 0.83 | OPRM1 (0.64) | OPRK1OPRM1OPRD1HDAC1TMEM97 | |
| SCHEMBL4075949 | 0.82 | OPRM1 (0.57) | OPRK1OPRM1OPRD1HDAC1TMEM97 | |
| SCHEMBL4084233 | 0.79 | OPRM1 (0.57) | OPRK1OPRM1OPRD1HDAC1KDM1A | |
| SCHEMBL4487323 | 0.78 | OPRM1 (0.59) | OPRK1OPRM1OPRD1HDAC1TMEM97 | |
| SCHEMBL4487306 | 0.77 | OPRM1 (0.50) | OPRK1OPRM1OPRD1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615651-B2 | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof | PFIZER INC. (US) | 2009-11-10 | — | — | US | claimed |