Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 11/20 | 0.72 |
| ▸ | KDR | P35968 | 10/20 | 0.72 |
| ▸ | PRKAA1 | Q13131 | 8/20 | 0.72 |
| ▸ | PRKAA2 | P54646 | 7/20 | 0.72 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.72 |
| ▸ | TLK2 | Q86UE8 | 5/20 | 0.72 |
| ▸ | CSF1R | P07333 | 4/20 | 0.72 |
| ▸ | RIOK2 | Q9BVS4 | 3/20 | 0.72 |
| ▸ | TLK1 | Q9UKI8 | 3/20 | 0.72 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.72 |
| ▸ | PLK4 | O00444 | 3/20 | 0.72 |
| ▸ | DCLK1 | O15075 | 3/20 | 0.72 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.72 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.72 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.72 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.72 |
| ▸ | RPS6KA4 | O75676 | 3/20 | 0.72 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.72 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.72 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4200636 | 0.96 | PDGFRB (0.69) | PDGFRBKDRPRKAA1PRKAA2FGFR1 | |
| SCHEMBL14276328 | 0.93 | PDGFRB (0.72) | PDGFRBKDRPRKAA1PRKAA2FGFR1 | |
| SCHEMBL14301659 | 0.92 | PRKAA1 (0.72) | PDGFRBKDRPRKAA1PRKAA2FGFR1 | |
| SCHEMBL14276348 | 0.91 | KDR (0.72) | PDGFRBKDRPRKAA1PRKAA2FGFR1 | |
| SCHEMBL14276351 | 0.91 | PDGFRB (0.71) | PDGFRBKDRPRKAA1PRKAA2FGFR1 | |
| SCHEMBL14276346 | 0.90 | PDGFRB (0.68) | PDGFRBKDRPRKAA1PRKAA2FGFR1 | |
| SCHEMBL3074129 | 0.90 | PRKAA1 (0.73) | PDGFRBKDRPRKAA1PRKAA2FGFR1 | |
| SCHEMBL3057209 | 0.90 | PRKAA1 (0.73) | PDGFRBKDRPRKAA1PRKAA2FGFR1 | |
| SCHEMBL14276345 | 0.89 | KDR (0.69) | PDGFRBKDRPRKAA1PRKAA2FGFR1 | |
| SCHEMBL4352175 | 0.89 | PRKAA1 (0.71) | PDGFRBKDRPRKAA1PRKAA2FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686987-A4 | ADVANCED INDOLINONE BASED PROTEIN KINASE INHIBITORS | SCRIPPS RESEARCH INST (US) | 2009-02-25 | — | — | EP | disclosed |
| US-20080044881-A1 | Advanced Indolinone Based Protein Kinase Inhibitors | SCRIPPS RESEARCH INSTITUTE, THE | 2008-02-21 | — | — | US | disclosed |
| US-20080044881-A1 | Advanced Indolinone Based Protein Kinase Inhibitors | SCRIPPS RESEARCH INSTITUTE, THE | 2008-02-21 | — | — | US | disclosed |
| US-20080044881-A1 | Advanced Indolinone Based Protein Kinase Inhibitors | SCRIPPS RESEARCH INSTITUTE, THE | 2008-02-21 | — | — | US | disclosed |
| US-20060287381-A1 | Enhanced indolinone based protein kinase inhibitors | THE SCRIPPS RESEARCH INSTITUTE (US) | 2006-12-21 | — | — | US | disclosed |
| EP-1686987-A2 | ADVANCED INDOLINONE BASED PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2006-08-09 | — | — | EP | disclosed |
| WO-2005053614-A2 | ADVANCED INDOLINONE BASED PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-06-16 | — | — | WO | disclosed |
| WO-2005053686-A1 | INDOLINONE BASED PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287381-A1 | Enhanced indolinone based protein kinase inhibitors | PHKG1, PHKG2, PRKCH | PDGFRB 388/4885KDR 1562/4885PRKAA1 5/4885 |
| US-20080044881-A1 | Advanced Indolinone Based Protein Kinase Inhibitors | PHKG1, PHKG2, HIPK1 | PDGFRB 666/4885KDR 976/4885PRKAA1 27/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.