Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4509021 | 0.99 | LMNA (0.39) | LMNATRPM8MEN1KMT2AALDH1A1 | |
| SCHEMBL1447382 | 0.81 | LMNA (0.54) | LMNATRPM8ALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL4251064 | 0.80 | LMNA (0.52) | LMNATRPM8ALDH1A1NPSR1NPC1 | |
| SCHEMBL4025575 | 0.79 | LMNA (0.51) | LMNATRPM8ALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL4523198 | 0.75 | TRPM8 (0.33) | LMNATRPM8ALDH1A1RAB9AKDM4E | |
| SCHEMBL4027824 | 0.75 | LMNA (0.45) | LMNAALDH1A1NPSR1SMN1; SMN2NPC1 | |
| SCHEMBL4188901 | 0.73 | LMNA (0.34) | LMNAL3MBTL1 | |
| SCHEMBL4247716 | 0.70 | LMNA (0.41) | LMNANPC1RAB9AS1PR3 | |
| SCHEMBL2094200 | 0.68 | MEN1 (0.48) | LMNATRPM8MEN1KMT2AALDH1A1 | |
| SCHEMBL1447361 | 0.67 | LMNA (0.41) | LMNARAB9AKDM4EGAAS1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1485375-B1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2009-06-17 | — | — | EP | disclosed |