Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1447382 | 0.98 | LMNA (0.54) | LMNARAB9ANPC1PKMTAS1R3 | |
| SCHEMBL4251064 | 0.97 | LMNA (0.52) | LMNARAB9ANPC1PKMTAS1R3 | |
| SCHEMBL4027824 | 0.95 | LMNA (0.45) | LMNARAB9ANPC1PKMTAS1R3 | |
| SCHEMBL4247716 | 0.90 | LMNA (0.41) | LMNARAB9ANPC1PKMTAS1R3 | |
| SCHEMBL4020643 | 0.84 | LMNA (0.37) | LMNARAB9ANPC1GAAKDM4E | |
| SCHEMBL4509021 | 0.80 | LMNA (0.39) | LMNARAB9ANPC1TAS1R3TAS1R1 | |
| SCHEMBL4491202 | 0.79 | LMNA (0.41) | LMNARAB9ANPC1S1PR3GAA | |
| SCHEMBL1447361 | 0.77 | LMNA (0.41) | LMNARAB9ATAS1R3TAS1R1TAS1R2 | |
| SCHEMBL4021989 | 0.72 | TRPM8 (0.36) | LMNATAS1R3TAS1R1TAS1R2S1PR3 | |
| SCHEMBL1448022 | 0.67 | LMNA (0.37) | LMNATAS1R3TAS1R1TAS1R2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1485375-B1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2009-06-17 | — | — | EP | disclosed |