Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.76 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.76 |
| ▸ | HTR1A | P08908 | 2/20 | 0.76 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.76 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.76 |
| ▸ | DRD3 | P35462 | 2/20 | 0.76 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.76 |
| ▸ | MEN1 | O00255 | 1/20 | 0.76 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.76 |
| ▸ | DRD1 | P21728 | 1/20 | 0.76 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.76 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13913702 | 0.87 | KMT2A (0.78) | KMT2AADRA1AHTR1AADRA2AOPRM1 | |
| Melperone SCHEMBL146287 | 0.86 | KMT2A (1.00) | KMT2AADRA1AHTR1AADRA2AOPRM1 | |
| SCHEMBL22778808 | 0.86 | HTR1A (0.76) | KMT2AADRA1AHTR1AADRA2AOPRM1 | |
| SCHEMBL22778817 | 0.85 | CYP2J2 (0.60) | KMT2AADRA1AHTR1AADRA2AOPRM1 | |
| Melperone SCHEMBL1649537 | 0.85 | KMT2A (0.97) | KMT2AADRA1AHTR1AADRA2AOPRM1 | |
| SCHEMBL10537108 | 0.81 | KMT2A (0.68) | KMT2AADRA1AHTR1AADRA2AOPRM1 | |
| SCHEMBL22778847 | 0.81 | DRD2 (0.65) | KMT2AADRA1AHTR1AADRA2AOPRM1 | |
| SCHEMBL11678065 | 0.80 | KMT2A (0.67) | KMT2AADRA1AHTR1AADRA2AOPRM1 | |
| SCHEMBL4499983 | 0.80 | CYP2J2 (0.65) | CYP2J2SLC6A2SLC6A4 | |
| SCHEMBL11554538 | 0.79 | HRH3 (0.65) | KMT2AADRA1AHTR1AADRA2AOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067604-B2 | Process for production of carebastine | ALBANY MOLECULAR RESEARCH, INC. (US) | 2011-11-29 | — | — | US | disclosed |
| US-20110065923-A1 | PROCESS FOR PRODUCTION OF CAREBASTINE | ALBANY MOLECULAR RESEARCH, INC. (US) | 2011-03-17 | — | — | US | disclosed |
| US-7485651-B2 | Compounds with activity on muscarinic receptors | ACADIA PHARMACEUTICALS, INC. (US) | 2009-02-03 | — | — | US | disclosed |
| US-20080108618-A1 | COMPOUNDS WITH ACTIVITY ON MUSCARINIC RECEPTORS | BRANN MARK | 2008-05-08 | — | — | US | disclosed |
| US-20030144285-A1 | Compounds with activity on muscarinic receptors | BRANN MARK (US) | 2003-07-31 | — | — | US | disclosed |
| US-6528529-B1 | 4-Methoxy-1-(4-(2-methylphenyl)-4-oxo-1-butyl)piperidine | ACADIA PHARMACEUTICALS INC. | 2003-03-04 | — | — | US | disclosed |
| WO-2001005763-A2 | COMPOUNDS WITH ACTIVITY ON MUSCARINIC RECEPTORS | ACADIA PHARMACEUTICALS, INC. (US) | 2001-01-25 | — | — | WO | disclosed |
| EP-1068185-A1 | COMPOUNDS WITH ACTIVITY ON MUSCARINIC RECEPTORS | Acadia Pharmaceuticals Inc. (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999050247-A1 | COMPOUNDS WITH ACTIVITY ON MUSCARINIC RECEPTORS | ACADIA PHARMACEUTICALS, INC. (US) | 1999-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108618-A1 | COMPOUNDS WITH ACTIVITY ON MUSCARINIC RECEPTORS | CHRM3, CHRM2, CHRM1 | KMT2A 2878/4885ADRA1A 29/4885HTR1A 147/4885 |
| US-20030144285-A1 | Compounds with activity on muscarinic receptors | CHRM3, CHRM2, CHRM1 | KMT2A 2878/4885ADRA1A 29/4885HTR1A 147/4885 |
| US-20110065923-A1 | PROCESS FOR PRODUCTION OF CAREBASTINE | GABRE, GABRB3, GABRB2 | KMT2A 3418/4885ADRA1A 1947/4885HTR1A 4290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.