Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CCNC | P24863 | 2/20 | 0.37 |
| ▸ | CDK8 | P49336 | 2/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | MC3R | P41968 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16828783 | 0.81 | ERN1 (0.42) | SIRT3TDP1CCNCCDK8ERN1 | |
| SCHEMBL659061 | 0.80 | HCAR2 (0.42) | TDP1TSHRKDM4EPOLBHCAR2 | |
| SCHEMBL4528998 | 0.79 | SIRT3 (0.48) | SIRT3TDP1CCNCCDK8ERN1 | |
| SCHEMBL17802090 | 0.74 | ALDH1A1 (0.43) | TSHRKDM4E | |
| SCHEMBL31688820 | 0.72 | SIRT3 (0.60) | SIRT3TDP1CCNCCDK8ERN1 | |
| SCHEMBL5700120 | 0.72 | TDP1 (0.55) | SIRT3TDP1CCNCCDK8ERN1 | |
| SCHEMBL30694749 | 0.72 | TDP1 (0.55) | SIRT3TDP1CCNCCDK8ERN1 | |
| SCHEMBL1379680 | 0.72 | SIRT3 (0.60) | SIRT3TDP1CCNCCDK8ERN1 | |
| SCHEMBL30694754 | 0.72 | TDP1 (0.55) | SIRT3TDP1CCNCCDK8ERN1 | |
| SCHEMBL3170417 | 0.71 | METAP2 (0.48) | ERN1TSHRMAP4K4PARP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632865-B2 | Thioamides and salts thereof and cytokine production inhibitors containing both | ISHIHARA SANGYO KAISHA, LTD. (JP) | 2009-12-15 | — | — | US | disclosed |
| US-20070219215-A1 | Thioamides and Salts Thereof and Cytokine Production Inhibitors Containing Both | ISHIHARA SANGYO KAISHA, LTD (JP) | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070219215-A1 | Thioamides and Salts Thereof and Cytokine Production Inhibitors Containing Both | IFNG, TST, STAT6 | SIRT3 890/4885TDP1 4515/4885CCNC 222/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.