SCHEMBL4491592

SCHEMBL4491592

CCNS(=O)(=O)c1ccc(OCCCC(=O)O)c2oc(C(C)NC(=O)/C(C#N)=C(\C)O)cc12

nearest known ligand 0.37

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
FABP4 P15090 4/20 0.37
DHODH Q02127 8/20 0.32
TSHR P16473 3/20 0.31
ACLY P53396 1/20 0.31
CYSLTR2 Q9NS75 3/20 0.30
CYSLTR1 Q9Y271 3/20 0.30
HPGD P15428 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4491599 1.00 FABP4 (0.37) FABP4DHODHTSHRACLYCYSLTR2
SCHEMBL4491596 1.00 FABP4 (0.37) FABP4DHODHTSHRACLYCYSLTR2
SCHEMBL6002124 0.84 FABP4 (0.37) FABP4DHODHTSHRACLYCYSLTR2
SCHEMBL6002119 0.84 FABP4 (0.37) FABP4DHODHTSHRACLYCYSLTR2
SCHEMBL4516114 0.79 CNR2 (0.43) DHODHTSHR
SCHEMBL4516119 0.79 CNR2 (0.43) DHODHTSHR
SCHEMBL4516121 0.79 CNR2 (0.43) DHODHTSHR
SCHEMBL4516304 0.71 ACACB (0.34) TSHRHPGD
SCHEMBL4511261 0.70 LTB4R (0.46) FABP4TSHRHPGD
SCHEMBL4511259 0.70 LTB4R (0.46) FABP4TSHRHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7638540-B2 Benzofuran compound and medicinal composition containing the same THE NEW INDUSTRY RESEARCH ORGANIZATION (JP) 2009-12-29 US disclosed
US-7638540-B2 Benzofuran compound and medicinal composition containing the same THE NEW INDUSTRY RESEARCH ORGANIZATION (JP) 2009-12-29 US disclosed
US-7638540-B2 Benzofuran compound and medicinal composition containing the same THE NEW INDUSTRY RESEARCH ORGANIZATION (JP) 2009-12-29 US disclosed
US-20060194851-A1 Benzofuran compound and medicinal composition containing the same NEW INDUSTRY RESEARCH ORGANIZATION, THE (JP) 2006-08-31 US disclosed
EP-1627873-A1 BENZOFURAN COMPOUND AND MEDICINAL COMPOSITION CONTAINING THE SAME The New Industry Research Organization (JP) 2006-02-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060194851-A1 Benzofuran compound and medicinal composition containing the same LTB4R2, LTC4S, LTB4R FABP4 747/4885DHODH 789/4885TSHR 4622/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.