SCHEMBL4492283

SCHEMBL4492283

O=C(CCCCCCOc1ccccc1)Nc1ccncn1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.62
MAPK1 P28482 1/20 0.62
L3MBTL1 Q9Y468 1/20 0.62
HDAC1 Q13547 4/20 0.58
HDAC2 Q92769 4/20 0.58
LMNA P02545 1/20 0.57
ALDH1A1 P00352 5/20 0.56
HDAC3 O15379 3/20 0.53
HDAC4 P56524 3/20 0.53
HDAC7 Q8WUI4 3/20 0.53
HDAC10 Q969S8 3/20 0.53
HDAC11 Q96DB2 3/20 0.53
HDAC8 Q9BY41 3/20 0.53
HDAC6 Q9UBN7 3/20 0.53
HDAC9 Q9UKV0 3/20 0.53
HDAC5 Q9UQL6 3/20 0.53
HTT P42858 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
CYP1A2 P05177 1/20 0.49
CYP3A4 P08684 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4466292 1.00 TSHR (0.62) TSHRMAPK1L3MBTL1HDAC1HDAC2
SCHEMBL16596278 0.86 CNR1 (0.48) TSHRMAPK1L3MBTL1HDAC1HDAC2
SCHEMBL6683882 0.82 LMNA (0.67) L3MBTL1LMNASMN1; SMN2GAA
SCHEMBL16596334 0.80 DEGS1 (0.62) MAPK1L3MBTL1HDAC1HDAC2LMNA
SCHEMBL4490206 0.79 HDAC3 (0.59) HDAC1HDAC2ALDH1A1HDAC3HDAC4
SCHEMBL896635 0.74 CHRNB2 (0.52) LMNAALDH1A1HTTSMN1; SMN2CYP1A2
SCHEMBL4557710 0.74 DEGS1 (0.60) ALDH1A1GAA
SCHEMBL19177369 0.73 RAB9A (0.49) MAPK1L3MBTL1ALDH1A1SMN1; SMN2GAA
SCHEMBL21533489 0.73 LMNA (0.73) TSHRMAPK1L3MBTL1LMNAALDH1A1
SCHEMBL21533494 0.73 LMNA (0.73) TSHRMAPK1L3MBTL1LMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2061772-A2 MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS Curis, Inc. (US) 2009-05-27 EP disclosed
WO-2008033747-A9 MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS CURIS INC (MA) 2008-07-24 WO disclosed
WO-2008033747-A2 MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS CURIS, INC. (US) 2008-03-20 WO disclosed