Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KHK | P50053 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
| ▸ | EIF4E | P06730 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4503148 | 0.83 | HTT (0.36) | GPR119HTTEIF4EMKNK1MKNK2 | |
| SCHEMBL12170572 | 0.80 | EIF4E (0.46) | GPR119CRHR1HTTEIF4EMKNK1 | |
| SCHEMBL375962 | 0.73 | GPR119 (0.61) | GPR119 | |
| SCHEMBL4488064 | 0.69 | GPR119 (0.50) | ALDH1A1GPR119CRHR1JAK2JAK3 | |
| SCHEMBL4491806 | 0.68 | GPR119 (0.37) | ALDH1A1GPR119HTTLRRK2 | |
| SCHEMBL12188759 | 0.66 | GPR119 (0.40) | ALDH1A1GPR119CRHR1JAK2JAK3 | |
| SCHEMBL4497686 | 0.66 | HTT (0.37) | GPR119HTTEIF4EMKNK1MKNK2 | |
| SCHEMBL21664340 | 0.65 | IRAK4 (0.43) | ALDH1A1KHKTRPV4EGLN2 | |
| SCHEMBL16858600 | 0.65 | KHK (0.40) | ALDH1A1KHKTRPV4EGLN2 | |
| SCHEMBL4502152 | 0.65 | P2RX7 (0.38) | ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8222261-B2 | Chemical compounds | GlaxoSmithKline, LLC (US) | 2012-07-17 | — | — | US | disclosed |
| US-20090318477-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318477-A1 | CHEMICAL COMPOUNDS | GPR119, GOT2, SLC5A2 | ALDH1A1 350/4885KHK 1038/4885GPR119 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.